Strategies for repair and remyelination in demyelinating diseases - PubMed (original) (raw)
Review
Strategies for repair and remyelination in demyelinating diseases
N Scolding. Curr Opin Neurol. 1997 Jun.
Abstract
A variety of therapeutic approaches aimed towards promoting myelin repair in multiple sclerosis and in other demyelinating diseases are now on the brink of clinical implementation. In this article, the extensive experimental studies of the past 2 decades, and in particular the considerable progress made over the last 12 months, will be briefly reviewed. A number of hurdles remain, together with practical and ethical problems which may be more difficult to solve; nevertheless, increasing excitement is apparent in this novel therapeutic field, and the rapid progress emerging from these laboratory based studies justifies a cautious optimism towards the successful translation of remyelination strategies from experimental neurobiology to clinical neurology.
Similar articles
- Clinical implications of myelin regeneration in the central nervous system.
McMurran CE, Kodali S, Young A, Franklin RJ. McMurran CE, et al. Expert Rev Neurother. 2018 Feb;18(2):111-123. doi: 10.1080/14737175.2018.1421458. Epub 2018 Jan 3. Expert Rev Neurother. 2018. PMID: 29285954 Review. - Demyelinating diseases and potential repair strategies.
Radtke C, Spies M, Sasaki M, Vogt PM, Kocsis JD. Radtke C, et al. Int J Dev Neurosci. 2007 May;25(3):149-53. doi: 10.1016/j.ijdevneu.2007.02.002. Epub 2007 Mar 3. Int J Dev Neurosci. 2007. PMID: 17408905 Free PMC article. Review. - Cellular approaches for stimulating CNS remyelination.
Miller RH, Bai L. Miller RH, et al. Regen Med. 2007 Sep;2(5):817-29. doi: 10.2217/17460751.2.5.817. Regen Med. 2007. PMID: 17907933 Review. - Prospects of cell therapy for disorders of myelin.
Ben-Hur T, Goldman SA. Ben-Hur T, et al. Ann N Y Acad Sci. 2008 Oct;1142:218-49. doi: 10.1196/annals.1444.014. Ann N Y Acad Sci. 2008. PMID: 18990129 Review. - Heterogeneity of pathogenesis in multiple sclerosis: implications for promotion of remyelination.
Paz Soldan MM, Rodriguez M. Paz Soldan MM, et al. J Infect Dis. 2002 Dec 1;186 Suppl 2:S248-53. doi: 10.1086/344283. J Infect Dis. 2002. PMID: 12424705 Review.
Cited by
- Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter.
Roy NS, Wang S, Harrison-Restelli C, Benraiss A, Fraser RA, Gravel M, Braun PE, Goldman SA. Roy NS, et al. J Neurosci. 1999 Nov 15;19(22):9986-95. doi: 10.1523/JNEUROSCI.19-22-09986.1999. J Neurosci. 1999. PMID: 10559406 Free PMC article. - Adult stem cells and multiple sclerosis.
Scolding N. Scolding N. Cell Prolif. 2011 Apr;44 Suppl 1(Suppl 1):35-8. doi: 10.1111/j.1365-2184.2010.00721.x. Cell Prolif. 2011. PMID: 21481041 Free PMC article. - Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve.
Shi J, Marinovich A, Barres BA. Shi J, et al. J Neurosci. 1998 Jun 15;18(12):4627-36. doi: 10.1523/JNEUROSCI.18-12-04627.1998. J Neurosci. 1998. PMID: 9614237 Free PMC article. - Therapeutic strategies in multiple sclerosis. II. Long-term repair.
Scolding N. Scolding N. Philos Trans R Soc Lond B Biol Sci. 1999 Oct 29;354(1390):1711-20. doi: 10.1098/rstb.1999.0514. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10603622 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous