FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation - PubMed (original) (raw)
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation
A P Tsang et al. Cell. 1997.
Free article
Abstract
The hematopoietic transcription factor GATA-1 is essential for development of the erythroid and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of GATA-1 in the yeast two-hybrid system, we have identified a novel, multitype zinc finger protein, Friend of GATA-1 (FOG), which binds GATA-1 but not a functionally inactive mutant lacking the amino (N) finger. FOG is coexpressed with GATA-1 during embryonic development and in erythroid and megakaryocytic cells. Furthermore, FOG and GATA-1 synergistically activate transcription from a hematopoietic-specific regulatory region and cooperate during both erythroid and megakaryocytic cell differentiation. These findings indicate that FOG acts as a cofactor for GATA-1 and provide a paradigm for the regulation of cell type-specific gene expression by GATA transcription factors.
Similar articles
- GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis.
Chang AN, Cantor AB, Fujiwara Y, Lodish MB, Droho S, Crispino JD, Orkin SH. Chang AN, et al. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9237-42. doi: 10.1073/pnas.142302099. Epub 2002 Jun 20. Proc Natl Acad Sci U S A. 2002. PMID: 12077323 Free PMC article. - The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.
Visvader JE, Crossley M, Hill J, Orkin SH, Adams JM. Visvader JE, et al. Mol Cell Biol. 1995 Feb;15(2):634-41. doi: 10.1128/MCB.15.2.634. Mol Cell Biol. 1995. PMID: 7823932 Free PMC article. - FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
Tevosian SG, Deconinck AE, Cantor AB, Rieff HI, Fujiwara Y, Corfas G, Orkin SH. Tevosian SG, et al. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):950-5. doi: 10.1073/pnas.96.3.950. Proc Natl Acad Sci U S A. 1999. PMID: 9927674 Free PMC article. - Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins.
Cantor AB, Orkin SH. Cantor AB, et al. Semin Cell Dev Biol. 2005 Feb;16(1):117-28. doi: 10.1016/j.semcdb.2004.10.006. Epub 2004 Dec 15. Semin Cell Dev Biol. 2005. PMID: 15659346 Review. - GATA-1: friends, brothers, and coworkers.
Morceau F, Schnekenburger M, Dicato M, Diederich M. Morceau F, et al. Ann N Y Acad Sci. 2004 Dec;1030:537-54. doi: 10.1196/annals.1329.064. Ann N Y Acad Sci. 2004. PMID: 15659837 Review.
Cited by
- Erythropoiesis: insights from a genomic perspective.
Cha HJ. Cha HJ. Exp Mol Med. 2024 Oct;56(10):2099-2104. doi: 10.1038/s12276-024-01311-1. Epub 2024 Oct 1. Exp Mol Med. 2024. PMID: 39349824 Free PMC article. Review. - Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development.
Fedl AS, Tagoh H, Gruenbacher S, Sun Q, Schenk RL, Froussios K, Jaritz M, Busslinger M, Schwickert TA. Fedl AS, et al. Nat Immunol. 2024 Sep;25(9):1663-1677. doi: 10.1038/s41590-024-01933-7. Epub 2024 Aug 23. Nat Immunol. 2024. PMID: 39179932 - GATA1 in Normal and Pathologic Megakaryopoiesis and Platelet Development.
Takasaki K, Chou ST. Takasaki K, et al. Adv Exp Med Biol. 2024;1459:261-287. doi: 10.1007/978-3-031-62731-6_12. Adv Exp Med Biol. 2024. PMID: 39017848 Review. - Endogenous small molecule effectors in GATA transcription factor mechanisms governing biological and pathological processes.
Liao R, Bresnick EH. Liao R, et al. Exp Hematol. 2024 Sep;137:104252. doi: 10.1016/j.exphem.2024.104252. Epub 2024 Jun 12. Exp Hematol. 2024. PMID: 38876253 Review. - Building Synthetic Biosensors Using Red Blood Cell Proteins.
Dolberg TB, Gunnels TF, Ling T, Sarnese KA, Crispino JD, Leonard JN. Dolberg TB, et al. ACS Synth Biol. 2024 Apr 19;13(4):1273-1289. doi: 10.1021/acssynbio.3c00754. Epub 2024 Mar 27. ACS Synth Biol. 2024. PMID: 38536408
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases