A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade - PubMed (original) (raw)
. 1997 Jul 17;388(6639):243-9.
doi: 10.1038/40805.
Affiliations
- PMID: 9230432
- DOI: 10.1038/40805
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade
S Tsunoda et al. Nature. 1997.
Abstract
How are signalling molecules organized into different pathways within the same cell? In Drosophila, the inaD gene encodes a protein consisting of five PDZ domains which serves as a scaffold to assemble different components of the phototransduction cascade, including the principal light-activated ion channels, the effector phospholipase C-beta and protein kinase C. Null inaD mutants have a dramatically reorganized subcellular distribution of signalling molecules, and a total loss of transduction complexes. Also, mutants defective in a single PDZ domain produce signalling complexes that lack the target protein and display corresponding defects in their physiology. A picture emerges of a highly organized unit of signalling, a 'transduclisome', with PDZ domains functioning as key elements in the organization of transduction complexes in vivo.
Similar articles
- Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling.
van Huizen R, Miller K, Chen DM, Li Y, Lai ZC, Raab RW, Stark WS, Shortridge RD, Li M. van Huizen R, et al. EMBO J. 1998 Apr 15;17(8):2285-97. doi: 10.1093/emboj/17.8.2285. EMBO J. 1998. PMID: 9545241 Free PMC article. - Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses.
Scott K, Zuker CS. Scott K, et al. Nature. 1998 Oct 22;395(6704):805-8. doi: 10.1038/27448. Nature. 1998. PMID: 9796815 - PDZ domain proteins: scaffolds for signaling complexes.
Ranganathan R, Ross EM. Ranganathan R, et al. Curr Biol. 1997 Dec 1;7(12):R770-3. doi: 10.1016/s0960-9822(06)00401-5. Curr Biol. 1997. PMID: 9382826 Review. - The roles of PDZ-containing proteins in PLC-beta-mediated signaling.
Suh PG, Hwang JI, Ryu SH, Donowitz M, Kim JH. Suh PG, et al. Biochem Biophys Res Commun. 2001 Oct 19;288(1):1-7. doi: 10.1006/bbrc.2001.5710. Biochem Biophys Res Commun. 2001. PMID: 11594744 Review.
Cited by
- Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature's Design?
Leslie KG, Berry SS, Miller GJ, Mahon CS. Leslie KG, et al. J Am Chem Soc. 2024 Oct 9;146(40):27215-27232. doi: 10.1021/jacs.4c08818. Epub 2024 Sep 28. J Am Chem Soc. 2024. PMID: 39340450 Free PMC article. Review. - An Update on Protein Kinases as Therapeutic Targets-Part I: Protein Kinase C Activation and Its Role in Cancer and Cardiovascular Diseases.
Silnitsky S, Rubin SJS, Zerihun M, Qvit N. Silnitsky S, et al. Int J Mol Sci. 2023 Dec 18;24(24):17600. doi: 10.3390/ijms242417600. Int J Mol Sci. 2023. PMID: 38139428 Free PMC article. Review. - Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.
Križaj D, Cordeiro S, Strauß O. Križaj D, et al. Prog Retin Eye Res. 2023 Jan;92:101114. doi: 10.1016/j.preteyeres.2022.101114. Epub 2022 Sep 24. Prog Retin Eye Res. 2023. PMID: 36163161 Free PMC article. Review. - The Role of Membrane Lipids in Light-Activation of Drosophila TRP Channels.
Gutorov R, Katz B, Rhodes-Mordov E, Zaguri R, Brandwine-Shemmer T, Minke B. Gutorov R, et al. Biomolecules. 2022 Feb 28;12(3):382. doi: 10.3390/biom12030382. Biomolecules. 2022. PMID: 35327573 Free PMC article. Review. - Molecular Evolution of Phototransduction Pathway Genes in Nocturnal and Diurnal Fireflies (Coleoptera: Lampyridae).
Martin GJ, Lower SE, Suvorov A, Bybee SM. Martin GJ, et al. Insects. 2021 Jun 18;12(6):561. doi: 10.3390/insects12060561. Insects. 2021. PMID: 34207188 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases