Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection - PubMed (original) (raw)

Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection

S A Rezende et al. Infect Immun. 1997 Aug.

Abstract

The egg-induced granulomatous reaction in Schistosoma mansoni-infected individuals develops within the portal system of the liver and is the major pathological finding in schistosomiasis. We have infected mice lacking the gamma interferon (IFN-gamma) receptor with S. mansoni larvae and studied the development of hepatic granulomas in these mutant mice in comparison to that in control wild-type mice. In the absence of IFN-gamma activity, a dramatic reduction in the size and architecture of the granuloma was observed. Granulomas from mutant mice were smaller than those from the control group and showed a significant reduction in the number of infiltrating inflammatory cells. Moreover, they appear to prematurely progress to the chronic phase of the reaction at a time when the control group still has acute inflammation. Our data suggests a pivotal role for IFN-gamma in the early events of the granulomatous reaction in vivo.

PubMed Disclaimer

Cited by

Biologic functions of the IFN-gamma receptors.
Tau G, Rothman P. Tau G, et al. Allergy. 1999 Dec;54(12):1233-51. doi: 10.1034/j.1398-9995.1999.00099.x. Allergy. 1999. PMID: 10688427 Free PMC article. Review.
Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection.
Rutitzky LI, Hernandez HJ, Stadecker MJ. Rutitzky LI, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13243-8. doi: 10.1073/pnas.231258498. Epub 2001 Oct 23. Proc Natl Acad Sci U S A. 2001. PMID: 11606762 Free PMC article.
Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses.
Mountford AP, Coulson PS, Cheever AW, Sher A, Wilson RA, Wynn TA. Mountford AP, et al. Immunology. 1999 Aug;97(4):588-94. doi: 10.1046/j.1365-2567.1999.00832.x. Immunology. 1999. PMID: 10457211 Free PMC article.
Immunopathology of schistosomiasis.
Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA. Wilson MS, et al. Immunol Cell Biol. 2007 Feb-Mar;85(2):148-54. doi: 10.1038/sj.icb.7100014. Epub 2006 Dec 12. Immunol Cell Biol. 2007. PMID: 17160074 Free PMC article. Review.
HTLV-1 modifies the clinical and immunological response to schistosomiasis.
Porto AF, Santos SB, Alcantara L, Guerreiro JB, Passos J, Gonzalez T, Neva F, Gonzalez D, Ho JL, Carvalho EM. Porto AF, et al. Clin Exp Immunol. 2004 Aug;137(2):424-9. doi: 10.1111/j.1365-2249.2004.02508.x. Clin Exp Immunol. 2004. PMID: 15270862 Free PMC article.

References

1. Eur J Immunol. 1990 Aug;20(8):1661-7 - PubMed
1. Infect Immun. 1995 Jul;63(7):2532-6 - PubMed
1. Exp Parasitol. 1974 Dec;36(3):360-72 - PubMed
1. Parasite Immunol. 1989 Nov;11(6):695-711 - PubMed
1. Infect Immun. 1991 Nov;59(11):4071-4 - PubMed

Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection - PubMed (original) (raw)