The expression of the imprinted genes H19 and IGF-2 in choriocarcinoma cell lines. Is H19 a tumor suppressor gene? - PubMed (original) (raw)

. 1997 Jul 10;15(2):169-77.

doi: 10.1038/sj.onc.1201175.

Affiliations

• PMID: 9244352
• DOI: 10.1038/sj.onc.1201175

The expression of the imprinted genes H19 and IGF-2 in choriocarcinoma cell lines. Is H19 a tumor suppressor gene?

O Lustig-Yariv et al. Oncogene. 1997.

Abstract

H19 is a paternally imprinted gene with unknown function. It is located in close proximity to the maternally imprinted IGF-2 gene on chromosome 11p15.5. In this study no consistent relationship between the expression of these two genes in clones derived from JEG-3 and JAr cell lines could be detected. Nor could a consistent relationship be detected between the expression levels of these two genes and between certain characteristic tumorigenic properties of these clones. We included in this study clones, expressing low H19 levels, which after transfection with an H19 expression construct highly expressed the H19 gene. In tumors, formed by the injection of cells of JAr or JEG-3 clones into nude mice, the H19 expression was high and irrelevant to the expression level in the cells before the injection. The same phenomenon was found for IGF-2 expression during tumorigenesis caused by cells of different JEG-3 clones and in some but not all JAr derived clones. Both H19 and IGF-2 are biallelicly expressed in all the JAr and JEG-3 clones. In summary, our observations point to the conclusion that H19 is not a tumor suppressor gene. However, its high expression in all the tumors formed after injection of cells of the JAr and JEG-3 clones, leaves its role, if any, in choriocarcinogenesis an open question.

PubMed Disclaimer

Similar articles

• H19 expression and tumorigenicity of choriocarcinoma derived cell lines.
  Rachmilewitz J, Elkin M, Rosensaft J, Gelman-Kohan Z, Ariel I, Lustig O, Schneider T, Goshen R, Biran H, de Groot N, et al. Rachmilewitz J, et al. Oncogene. 1995 Sep 7;11(5):863-70. Oncogene. 1995. PMID: 7545806
• Proinsulin-like growth factor-II overexpression does not alter monoallelic H19 gene expression in transfected human embryonic kidney fibroblasts.
  Kiess W, Paquette J, Koepf G, Wolf E, Deal C. Kiess W, et al. Biochem Biophys Res Commun. 1999 Feb 16;255(2):226-30. doi: 10.1006/bbrc.1999.0187. Biochem Biophys Res Commun. 1999. PMID: 10049690
• Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells.
  He L, Cui H, Walsh C, Mattsson R, Lin W, Anneren G, Pfeifer-Ohlsson S, Ohlsson R. He L, et al. Oncogene. 1998 Jan 8;16(1):113-9. doi: 10.1038/sj.onc.1201501. Oncogene. 1998. PMID: 9467950
• Involvement of IGF2 and H19 imprinting in choriocarcinoma development.
  Wake N, Arima T, Matsuda T. Wake N, et al. Int J Gynaecol Obstet. 1998 Apr;60 Suppl 1:S1-8. Int J Gynaecol Obstet. 1998. PMID: 9833609 Review.
• H19 in normal development and neoplasia.
  Looijenga LH, Verkerk AJ, De Groot N, Hochberg AA, Oosterhuis JW. Looijenga LH, et al. Mol Reprod Dev. 1997 Mar;46(3):419-39. doi: 10.1002/(SICI)1098-2795(199703)46:3<419::AID-MRD22>3.0.CO;2-S. Mol Reprod Dev. 1997. PMID: 9041146 Review. No abstract available.

Cited by

• Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases.
  Liao J, Chen B, Zhu Z, Du C, Gao S, Zhao G, Zhao P, Wang Y, Wang A, Schwartz Z, Song L, Hong J, Wagstaff W, Haydon RC, Luu HH, Fan J, Reid RR, He TC, Shi L, Hu N, Huang W. Liao J, et al. Genes Dis. 2023 Mar 24;10(4):1351-1366. doi: 10.1016/j.gendis.2023.02.008. eCollection 2023 Jul. Genes Dis. 2023. PMID: 37397543 Free PMC article. Review.
• LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes.
  Xu A, Huang MF, Zhu D, Gingold JA, Bazer DA, Chang B, Wang D, Lai CC, Lemischka IR, Zhao R, Lee DF. Xu A, et al. Front Genet. 2021 Jan 15;11:611823. doi: 10.3389/fgene.2020.611823. eCollection 2020. Front Genet. 2021. PMID: 33519915 Free PMC article.
• H19 gene polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study.
  Li W, Hua RX, Wang M, Zhang D, Zhu J, Zhang S, Yang Y, Cheng J, Zhou H, Zhang J, He J. Li W, et al. Mol Genet Genomic Med. 2021 Feb;9(2):e1584. doi: 10.1002/mgg3.1584. Epub 2021 Jan 5. Mol Genet Genomic Med. 2021. PMID: 33403826 Free PMC article.
• Are Long Noncoding RNAs New Potential Biomarkers in Gastrointestinal Stromal Tumors (GISTs)? The Role of H19 and MALAT1.
  Badalamenti G, Barraco N, Incorvaia L, Galvano A, Fanale D, Cabibi D, Calò V, Currò G, Bazan V, Russo A. Badalamenti G, et al. J Oncol. 2019 Nov 15;2019:5458717. doi: 10.1155/2019/5458717. eCollection 2019. J Oncol. 2019. PMID: 31827510 Free PMC article.
• Targeted Diphtheria Toxin-Based Therapy: A Review Article.
  Shafiee F, Aucoin MG, Jahanian-Najafabadi A. Shafiee F, et al. Front Microbiol. 2019 Oct 18;10:2340. doi: 10.3389/fmicb.2019.02340. eCollection 2019. Front Microbiol. 2019. PMID: 31681205 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations

• Miscellaneous

  • NCI CPTAC Assay Portal