The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4 - PubMed (original) (raw)
The chemokine SDF-1, stromal cell-derived factor 1, attracts early stage B cell precursors via the chemokine receptor CXCR4
M D'Apuzzo et al. Eur J Immunol. 1997 Jul.
Abstract
In the bone marrow, progenitor (pro-) and precursor (pre-) B cells depend on close contact with stromal cells for growth and maturation. Stromal cell-derived factor 1 (SDF-1), also known as pre-B cell growth-stimulating factor, is produced by bone marrow stromal cells and was reported to act together with interleukin-7 as co-mitogen for pre-B cells. SDF-1 was recently shown to be a chemokine which is chemotactic for different types of leukocytes and acts via the chemokine receptor CXCR4. Using sorted B220+ bone marrow cells and several B cell lines characteristic for different stages of B lymphopoiesis, we now show that SDF-1 is a potent attractant for pro- and pre-B cells, but is inactive on B cells at later stages of development. In early B cell precursors, SDF-1 induced intracellular Ca2+ mobilization and in vitro migration with a potency and efficacy similar to that observed for chemokines acting on blood leukocytes. These responses were mediated via CXCR4 as they could be inhibited by an antireceptor antibody. SDF-1 is the first chemokine shown to act on early-stage B cell precursors. Mice lacking SDF-1 die perinatally and show a severe deficiency in B lymphopoiesis. We propose that SDF-1 released from the stromal cells exerts its critical hematopoietic function by selectively attracting and confining early B cell precursors within the bone marrow microenvironment that provides the necessary factors for growth and differentiation.
Similar articles
- Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts.
Wright LM, Maloney W, Yu X, Kindle L, Collin-Osdoby P, Osdoby P. Wright LM, et al. Bone. 2005 May;36(5):840-53. doi: 10.1016/j.bone.2005.01.021. Epub 2005 Mar 24. Bone. 2005. PMID: 15794931 - Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration.
Yu X, Huang Y, Collin-Osdoby P, Osdoby P. Yu X, et al. J Bone Miner Res. 2003 Aug;18(8):1404-18. doi: 10.1359/jbmr.2003.18.8.1404. J Bone Miner Res. 2003. PMID: 12929930 - A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis.
Nagasawa T. Nagasawa T. Int J Hematol. 2000 Dec;72(4):408-11. Int J Hematol. 2000. PMID: 11197205 Review.
Cited by
- Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.
Fukuoka A, Wilson GJ, Pitmon E, Koumbas Foley L, Johnsson H, Pingen M, Graham GJ. Fukuoka A, et al. Development. 2024 Feb 15;151(4):dev202333. doi: 10.1242/dev.202333. Epub 2024 Feb 23. Development. 2024. PMID: 38300826 Free PMC article. - Prognostic significance of plasma SDF-1 in acute ischemic stroke patients with diabetes mellitus: the CATIS trial.
You S, Chen H, Miao M, Du J, Che B, Xu T, Liu CF, Zhang Y, He J, Zhong X, Cao Y, Zhong C. You S, et al. Cardiovasc Diabetol. 2023 Oct 10;22(1):274. doi: 10.1186/s12933-023-01996-0. Cardiovasc Diabetol. 2023. PMID: 37817149 Free PMC article. - FTY720 in immuno-regenerative and wound healing technologies for muscle, epithelial and bone regeneration.
Behara M, Goudy S. Behara M, et al. Front Physiol. 2023 May 12;14:1148932. doi: 10.3389/fphys.2023.1148932. eCollection 2023. Front Physiol. 2023. PMID: 37250137 Free PMC article. Review. - Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery.
Trivigno SMG, Guidetti GF, Barbieri SS, Zarà M. Trivigno SMG, et al. Int J Mol Sci. 2023 Apr 18;24(8):7462. doi: 10.3390/ijms24087462. Int J Mol Sci. 2023. PMID: 37108623 Free PMC article. Review. - CXCR4 mediates the effects of IGF-1R signaling in rodent bone homeostasis and fracture repair.
Esposito A, Klüppel M, Wilson BM, Meka SRK, Spagnoli A. Esposito A, et al. Bone. 2023 Jan;166:116600. doi: 10.1016/j.bone.2022.116600. Epub 2022 Nov 9. Bone. 2023. PMID: 36368465 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous