Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids - PubMed (original) (raw)
Comparative Study
Newborn piglet cerebral microvascular responses to epoxyeicosatrienoic acids
C W Leffler et al. Am J Physiol. 1997 Jul.
Abstract
The present study on the newborn pig cerebral microcirculation determined the vasoactive properties of epoxyeicosatrienoic acids (EETs) and the contributions of prostaglandin cyclooxygenase to these properties. Pial arterioles of anesthetized piglets were observed through closed cranial windows, EETs were applied topically, and artificial cerebrospinal fluid from beneath the cranial windows was collected for the determination of adenosine 3',5'-cyclic monophosphate and 6-ketoprostaglandin F1 alpha. EETs caused dilation of pial arterioles and increased adenosine 3',5'-cyclic monophosphate. 5,6-EET produced a dose-dependent dilation at 10(-8) M and above, whereas 10(-6) M was required for 8,9-EET, 11,12-EET, and 14,15-EET. Indomethacin abolished pial arteriolar dilation to the EETs. However, EETs did not increase cortical 6-ketoprostaglandin F1 alpha concentration. Treatment of indomethacin-treated piglets with iloprost (10(-12) M topically) restored dilation to 5,6-EET. Neither isoproterenol nor sodium nitroprusside allowed vasodilation to 5,6-EET in indomethacin-treated piglets. Therefore, in the newborn pig cerebral microvasculature. EETs are potent vasodilators and prostacyclin-receptor agonists are necessary to allow this dilation to occur.
Similar articles
- PTX-sensitive G proteins and permissive action of prostacyclin in newborn pig cerebral circulation.
Zucker B, Leffler CW. Zucker B, et al. Am J Physiol. 1998 Jul;275(1):H259-63. doi: 10.1152/ajpheart.1998.275.1.H259. Am J Physiol. 1998. PMID: 9688922 - Role of endothelin-1 in cerebral hematoma-induced modification of cerebral vascular reactivity in piglets.
Yakubu MA, Leffler CW. Yakubu MA, et al. Brain Res. 1996 Sep 23;734(1-2):149-56. Brain Res. 1996. PMID: 8896820 - Contributions of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets.
Leffler CW, Nasjletti A, Johnson RA, Fedinec AL. Leffler CW, et al. Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1490-5. doi: 10.1152/ajpheart.2001.280.4.H1490. Am J Physiol Heart Circ Physiol. 2001. PMID: 11247758 - Orally Active Epoxyeicosatrienoic Acid Analogs.
Campbell WB, Imig JD, Schmitz JM, Falck JR. Campbell WB, et al. J Cardiovasc Pharmacol. 2017 Oct;70(4):211-224. doi: 10.1097/FJC.0000000000000523. J Cardiovasc Pharmacol. 2017. PMID: 28937442 Free PMC article. Review. - Dual regulation of the cerebral microvasculature by epoxyeicosatrienoic acids.
Medhora M, Narayanan J, Harder D. Medhora M, et al. Trends Cardiovasc Med. 2001 Jan;11(1):38-42. doi: 10.1016/s1050-1738(01)00082-2. Trends Cardiovasc Med. 2001. PMID: 11413051 Review.
Cited by
- Regulation of the Cerebral Circulation During Development.
Koehler RC. Koehler RC. Compr Physiol. 2021 Sep 23;11(4):2371-2432. doi: 10.1002/cphy.c200028. Compr Physiol. 2021. PMID: 34558670 Free PMC article. - Cytochrome P450 eicosanoids in cerebrovascular function and disease.
Davis CM, Liu X, Alkayed NJ. Davis CM, et al. Pharmacol Ther. 2017 Nov;179:31-46. doi: 10.1016/j.pharmthera.2017.05.004. Epub 2017 May 18. Pharmacol Ther. 2017. PMID: 28527918 Free PMC article. Review. - 20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats.
Shaik JS, Poloyac SM, Kochanek PM, Alexander H, Tudorascu DL, Clark RS, Manole MD. Shaik JS, et al. J Cereb Blood Flow Metab. 2015 Nov;35(11):1757-63. doi: 10.1038/jcbfm.2015.117. Epub 2015 Jun 10. J Cereb Blood Flow Metab. 2015. PMID: 26058691 Free PMC article. - Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.
Birnie M, Morrison R, Camara R, Strauss KI. Birnie M, et al. BMC Genomics. 2013 May 4;14:303. doi: 10.1186/1471-2164-14-303. BMC Genomics. 2013. PMID: 23642095 Free PMC article. - Epoxides and soluble epoxide hydrolase in cardiovascular physiology.
Imig JD. Imig JD. Physiol Rev. 2012 Jan;92(1):101-30. doi: 10.1152/physrev.00021.2011. Physiol Rev. 2012. PMID: 22298653 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources