Telomerase catalytic subunit homologs from fission yeast and human - PubMed (original) (raw)
Telomerase catalytic subunit homologs from fission yeast and human
T M Nakamura et al. Science. 1997.
Abstract
Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified. Disruption of the S. pombe gene resulted in telomere shortening and senescence, and expression of mRNA from the human gene correlated with telomerase activity in cell lines. Sequence comparisons placed the telomerase proteins in the reverse transcriptase family but revealed hallmarks that distinguish them from retroviral and retrotransposon relatives. Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases.
Comment in
- Telomerase and retrotransposons: which came first?
Eickbush TH. Eickbush TH. Science. 1997 Aug 15;277(5328):911-2. doi: 10.1126/science.277.5328.911. Science. 1997. PMID: 9281073 No abstract available.
Similar articles
- Reverse transcriptase motifs in the catalytic subunit of telomerase.
Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Lingner J, et al. Science. 1997 Apr 25;276(5312):561-7. doi: 10.1126/science.276.5312.561. Science. 1997. PMID: 9110970 - Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.
Páez-Moscoso DJ, Pan L, Sigauke RF, Schroeder MR, Tang W, Baumann P. Páez-Moscoso DJ, et al. Nat Commun. 2018 Feb 8;9(1):587. doi: 10.1038/s41467-017-02284-8. Nat Commun. 2018. PMID: 29422664 Free PMC article. - Telomerase is a true reverse transcriptase. A review.
Cech TR, Nakamura TM, Lingner J. Cech TR, et al. Biochemistry (Mosc). 1997 Nov;62(11):1202-5. Biochemistry (Mosc). 1997. PMID: 9467843 Review. - TER1, the RNA subunit of fission yeast telomerase.
Leonardi J, Box JA, Bunch JT, Baumann P. Leonardi J, et al. Nat Struct Mol Biol. 2008 Jan;15(1):26-33. doi: 10.1038/nsmb1343. Epub 2007 Dec 23. Nat Struct Mol Biol. 2008. PMID: 18157152 - Telomerase RNA is more than a DNA template.
Webb CJ, Zakian VA. Webb CJ, et al. RNA Biol. 2016 Aug 2;13(8):683-9. doi: 10.1080/15476286.2016.1191725. Epub 2016 May 31. RNA Biol. 2016. PMID: 27245259 Free PMC article. Review.
Cited by
- Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.
Machitani M, Nomura A, Yamashita T, Yasukawa M, Ueki S, Fujita KI, Ueno T, Yamashita A, Tanzawa Y, Watanabe M, Taniguchi T, Saitoh N, Kaneko S, Kato Y, Mano H, Masutomi K. Machitani M, et al. Nat Cell Biol. 2024 Jun;26(6):932-945. doi: 10.1038/s41556-024-01427-6. Epub 2024 May 28. Nat Cell Biol. 2024. PMID: 38806647 - Therapeutic targeting of PLK1 in TERT promoter-mutant hepatocellular carcinoma.
Tang Q, Hu G, Sang Y, Chen Y, Wei G, Zhu M, Chen M, Li S, Liu R, Peng Z. Tang Q, et al. Clin Transl Med. 2024 May;14(5):e1703. doi: 10.1002/ctm2.1703. Clin Transl Med. 2024. PMID: 38769666 Free PMC article. - Transgenerational Seed Exposure to Elevated CO2 Involves Stress Memory Regulation at Metabolic Levels to Confer Drought Resistance in Wheat.
Shafique Ahmad K, Shehzad MA, Javid H, Mehmood A, Akhtar G, Zafar S, Mahroof S, Mahmoud EA, Elansary HO, Ulfat A, Abid H. Shafique Ahmad K, et al. ACS Omega. 2024 Apr 22;9(18):20042-20055. doi: 10.1021/acsomega.3c10379. eCollection 2024 May 7. ACS Omega. 2024. PMID: 38737051 Free PMC article. - Guardians of the Genome: How the Single-Stranded DNA-Binding Proteins RPA and CST Facilitate Telomere Replication.
Olson CL, Wuttke DS. Olson CL, et al. Biomolecules. 2024 Feb 22;14(3):263. doi: 10.3390/biom14030263. Biomolecules. 2024. PMID: 38540683 Free PMC article. Review. - A phase 1 trial of human telomerase reverse transcriptase (hTERT) vaccination combined with therapeutic strategies to control immune-suppressor mechanisms.
Zareian N, Eremin O, Pandha H, Baird R, Kwatra V, Funingana G, Verma C, Choy D, Hargreaves S, Moghimi P, Shepherd A, Lobo DN, Eremin J, Farzaneh F, Kordasti S, Spicer J. Zareian N, et al. Exp Biol Med (Maywood). 2024 Jan 31;249:10021. doi: 10.3389/ebm.2024.10021. eCollection 2024. Exp Biol Med (Maywood). 2024. PMID: 38463391 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases