Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants - PubMed (original) (raw)
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
M Roman et al. Nat Med. 1997 Aug.
Abstract
An adjuvant role for certain short bacterial immunostimulatory DNA sequences (ISSs) has recently been proposed on the basis of their ability to stimulate T helper-1 (Th1) responses in gene-vaccinated animals. We report here that noncoding, ISS-enriched plasmid DNAs or ISS oligonucleotides (ISS-ODNs) potently stimulate immune responses to coadministered antigens. The ISS-DNAs suppress IgE synthesis, but promote IgG and interferon-gamma (IFN-gamma) production. They furthermore initiate the production of IFN-gamma, IFN-alpha, IFN-beta, and interleukins 12 and 18, all of which foster Th1 responses and enhance cell-mediated immunity. Consideration should be given to adding noncoding DNA adjuvants to inactivated or subunit viral vaccines that, by themselves, provide only partial protection from infection.
Comment in
- Immunostimulatory DNA: a clear and present danger?
Pisetsky DS. Pisetsky DS. Nat Med. 1997 Aug;3(8):829-31. doi: 10.1038/nm0897-829. Nat Med. 1997. PMID: 9256266 No abstract available.
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