Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN-dependent anti-GBM nephritis in mice - PubMed (original) (raw)
. 1997 Jul-Aug;5(4):301-4.
Affiliations
- PMID: 9259184
Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN-dependent anti-GBM nephritis in mice
G W Feith et al. Exp Nephrol. 1997 Jul-Aug.
Abstract
Background: Intravenous administration of clodronate (dichloromethylene bisphosphate)-containing liposomes (clodro-L) has been reported to induce selective depletion of tissue macrophages (M phi) with little or no effect on polymorphonuclear granulocytes (PMN). Therefore, we used clodro-L treatment to study the role of M phi in a PMN-dependent model of anti-glomerular basement membrane (GBM) nephritis.
Methods: C57BL/6J mice received clodro-L i.v. at days -2 and -1 before i.v. injection of anti-GBM antibodies. The albuminuria of the first 24 h was measured by radial immunodiffusion in 18 hour urine samples and glomerular changes were studied histologically and immunohistologically.
Results: Treatment with clodro-L, in doses that adequately destroyed the Kupffer cells, failed to reduce glomerular M phi numbers, but markedly inhibited glomerular PMN accumulation. Compared to control mice, clodro-L-pretreated C57BL/6J mice showed considerable reduction of both albuminuria and glomerular damage at day 1 after injection of rabbit anti-GBM antibody.
Conclusions: In this PMN-dependent model, the inhibitory effect of clodro-L treatment on the development of nephritis very likely due to the inhibition of glomerular PMN accumulation. Our results indicate the clodro-L treatment as a method of selective M phi depletion has its limitations, especially in models in which PMN are involved as effector cells.
Similar articles
- Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Feith GW, Assmann KJ, Bogman MJ, van Gompel AP, Schalkwijk J, Koene RA. Feith GW, et al. Nephrol Dial Transplant. 1996 Apr;11(4):599-607. doi: 10.1093/oxfordjournals.ndt.a027347. Nephrol Dial Transplant. 1996. PMID: 8671846 - Cyclosporin A reduces albuminuria in experimental anti-GBM nephritis independently from changes in GFR.
Schrijver G, Assmann KJ, Wetzels JF, Berden JH. Schrijver G, et al. Nephrol Dial Transplant. 1995;10(7):1149-54. Nephrol Dial Transplant. 1995. PMID: 7478116 - Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats.
Isome M, Fujinaka H, Adhikary LP, Kovalenko P, El-Shemi AG, Yoshida Y, Yaoita E, Takeishi T, Takeya M, Naito M, Suzuki H, Yamamoto T. Isome M, et al. Nephrol Dial Transplant. 2004 Dec;19(12):2997-3004. doi: 10.1093/ndt/gfh558. Nephrol Dial Transplant. 2004. PMID: 15574997 - Glomerular crescents--composition and mediators.
Cattell V. Cattell V. Nephrologie. 1992;13(6):251-3. Nephrologie. 1992. PMID: 1299782 Review. No abstract available. - Liposome mediated modulation of macrophage functions.
van Rooijen N. van Rooijen N. Adv Exp Med Biol. 1994;355:69-74. doi: 10.1007/978-1-4615-2492-2_12. Adv Exp Med Biol. 1994. PMID: 7709846 Review. No abstract available.
Cited by
- Blocking of inflammatory heparan sulfate domains by specific antibodies is not protective in experimental glomerulonephritis.
van Gemst JJ, Passmann NJHG, Rops ALWMM, van Kuppevelt TH, Berden JH, Loeven MA, Rabelink TJ, Smeets B, van der Vlag J. van Gemst JJ, et al. PLoS One. 2021 Dec 23;16(12):e0261722. doi: 10.1371/journal.pone.0261722. eCollection 2021. PLoS One. 2021. PMID: 34941931 Free PMC article. - Human Clinical Relevance of the Porcine Model of Pseudoallergic Infusion Reactions.
Szebeni J, Bawa R. Szebeni J, et al. Biomedicines. 2020 Apr 8;8(4):82. doi: 10.3390/biomedicines8040082. Biomedicines. 2020. PMID: 32276476 Free PMC article. Review. - F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo.
Thompson HL, van Rooijen N, McLelland BT, Manilay JO. Thompson HL, et al. J Immunol Res. 2016;2016:2414906. doi: 10.1155/2016/2414906. Epub 2016 Oct 30. J Immunol Res. 2016. PMID: 27872864 Free PMC article. - Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis.
Xia Y, Campbell SR, Broder A, Herlitz L, Abadi M, Wu P, Michaelson JS, Burkly LC, Putterman C. Xia Y, et al. Clin Immunol. 2012 Nov;145(2):108-21. doi: 10.1016/j.clim.2012.08.008. Epub 2012 Aug 20. Clin Immunol. 2012. PMID: 22982296 Free PMC article. - Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury.
Dhaliwal K, Scholefield E, Ferenbach D, Gibbons M, Duffin R, Dorward DA, Morris AC, Humphries D, MacKinnon A, Wilkinson TS, Wallace WA, van Rooijen N, Mack M, Rossi AG, Davidson DJ, Hirani N, Hughes J, Haslett C, Simpson AJ. Dhaliwal K, et al. Am J Respir Crit Care Med. 2012 Sep 15;186(6):514-24. doi: 10.1164/rccm.201112-2132OC. Epub 2012 Jul 19. Am J Respir Crit Care Med. 2012. PMID: 22822022 Free PMC article.