Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 - PubMed (original) (raw)

. 1997 Aug 8;237(1):79-83.

doi: 10.1006/bbrc.1997.7080.

Affiliations

• PMID: 9266833
• DOI: 10.1006/bbrc.1997.7080

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3

S Minamoto et al. Biochem Biophys Res Commun. 1997.

Abstract

Upon the corresponding ligand's stimulation, the cytokine receptors activate several signal pathways: JAK-STAT pathway, Ras-MAP kinase pathway and so on. Recently, we demonstrated that one of the STAT3 (signal transducer and activator of transcription-3) target genes could suppress the function of STAT3 and designated as SSI-1(STAT induced STAT inhibitor-1). SSI-1 is thought to play a critical role in negative feedback control of JAK-STAT signaling pathway. In the present study, we identified two novel human genes which products have homologous region in their SH2 domain and its COOH-terminal region to mouse SSI-1. Northern blotting analysis and functional studies demonstrated that SSI-2 and SSI-3 mRNA were also induced by cytokine stimulation and their forced expression in mouse myeloid leukemia cell, M1, suppressed the apoptotic effect of LIF, like SSI-1. We also demonstrated the structure of human SSI-1.

PubMed Disclaimer

Similar articles

• Structure and function of a new STAT-induced STAT inhibitor.
  Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T. Naka T, et al. Nature. 1997 Jun 26;387(6636):924-9. doi: 10.1038/43219. Nature. 1997. PMID: 9202127
• gp130-Dependent signalling pathway is not enhanced in gp130 transgenic heart after LIF stimulation.
  Tone E, Kunisada K, Kumanogoh A, Negoro S, Funamoto M, Osugi T, Kishimoto T, Yamauchi-Takihara K. Tone E, et al. Cytokine. 2000 Oct;12(10):1512-8. doi: 10.1006/cyto.2000.0751. Cytokine. 2000. PMID: 11023666
• CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells.
  Suzuki R, Sakamoto H, Yasukawa H, Masuhara M, Wakioka T, Sasaki A, Yuge K, Komiya S, Inoue A, Yoshimura A. Suzuki R, et al. Oncogene. 1998 Oct 29;17(17):2271-8. doi: 10.1038/sj.onc.1202143. Oncogene. 1998. PMID: 9811457
• Negative regulation of cytokine signaling pathways.
  Yasukawa H, Sasaki A, Yoshimura A. Yasukawa H, et al. Annu Rev Immunol. 2000;18:143-64. doi: 10.1146/annurev.immunol.18.1.143. Annu Rev Immunol. 2000. PMID: 10837055 Review.
• The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling.
  Gisselbrecht S. Gisselbrecht S. Eur Cytokine Netw. 1999 Dec;10(4):463-70. Eur Cytokine Netw. 1999. PMID: 10586112 Review.

Cited by

• Twenty proteins containing a C-terminal SOCS box form five structural classes.
  Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA. Hilton DJ, et al. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9. doi: 10.1073/pnas.95.1.114. Proc Natl Acad Sci U S A. 1998. PMID: 9419338 Free PMC article.
• Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction.
  Losman JA, Chen XP, Hilton D, Rothman P. Losman JA, et al. J Immunol. 1999 Apr 1;162(7):3770-4. J Immunol. 1999. PMID: 10201892 Free PMC article.
• The cellular and molecular bases of leptin and ghrelin resistance in obesity.
  Cui H, López M, Rahmouni K. Cui H, et al. Nat Rev Endocrinol. 2017 Jun;13(6):338-351. doi: 10.1038/nrendo.2016.222. Epub 2017 Feb 24. Nat Rev Endocrinol. 2017. PMID: 28232667 Free PMC article. Review.
• Role of SOCS and VHL Proteins in Neuronal Differentiation and Development.
  Kanno H, Matsumoto S, Yoshizumi T, Nakahara K, Kubo A, Murata H, Shuin T, U HS. Kanno H, et al. Int J Mol Sci. 2023 Feb 15;24(4):3880. doi: 10.3390/ijms24043880. Int J Mol Sci. 2023. PMID: 36835292 Free PMC article. Review.
• IL-6: from laboratory to bedside.
  Kishimoto T. Kishimoto T. Clin Rev Allergy Immunol. 2005 Jun;28(3):177-86. doi: 10.1385/CRIAI:28:3:177. Clin Rev Allergy Immunol. 2005. PMID: 16129902 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal