Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants - PubMed (original) (raw)
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants
D A Sinclair et al. Science. 1997.
Abstract
The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmented-changes that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure.
Comment in
- Yeast as a model organism.
Botstein D, Chervitz SA, Cherry JM. Botstein D, et al. Science. 1997 Aug 29;277(5330):1259-60. doi: 10.1126/science.277.5330.1259. Science. 1997. PMID: 9297238 Free PMC article. No abstract available.
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