Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts - PubMed (original) (raw)
Review
. 1997 Sep 1;159(5):2075-7.
Affiliations
- PMID: 9278290
Review
Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts
F Vély et al. J Immunol. 1997.
Abstract
Immunoreceptor tyrosine-based inhibition motifs (ITIMs) consist of a 6-amino acid stretch (ILV)xYxx(LV). ITIMs are expressed in the intracytoplasmic domain of transmembrane receptors, which extinguish cell activation induced by receptors bearing immunoreceptor tyrosine-based activation motifs. The recent identification of new members of the ITIM-bearing receptor family (such as the signal-regulatory proteins) extends the ITIM concept to the negative regulation of growth factor- and oncogene-induced activation in nonhemopoietic cells. In addition, it appears that a feature of the family of ITIM-bearing receptors is the existence of noninhibitory/activatory counterparts devoid of intracytoplasmic ITIMs and characterized by the presence of a charged amino acid residue in their transmembrane domain.
Similar articles
- Natural killer cell signaling pathways.
Vivier E, Nunès JA, Vély F. Vivier E, et al. Science. 2004 Nov 26;306(5701):1517-9. doi: 10.1126/science.1103478. Science. 2004. PMID: 15567854 - Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future.
Daëron M, Jaeger S, Du Pasquier L, Vivier E. Daëron M, et al. Immunol Rev. 2008 Aug;224:11-43. doi: 10.1111/j.1600-065X.2008.00666.x. Immunol Rev. 2008. PMID: 18759918 Review. - Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.
Wang LL, Blasioli J, Plas DR, Thomas ML, Yokoyama WM. Wang LL, et al. J Immunol. 1999 Feb 1;162(3):1318-23. J Immunol. 1999. PMID: 9973385 - Intracellular signaling by the killer immunoglobulin-like receptors and Ly49.
McVicar DW, Burshtyn DN. McVicar DW, et al. Sci STKE. 2001 Mar 27;2001(75):re1. doi: 10.1126/stke.2001.75.re1. Sci STKE. 2001. PMID: 11752646 Review.
Cited by
- Evidence for Extensive Duplication and Subfunctionalization of FCRL6 in Armadillo (Dasypus novemcinctus).
Matos MC, Pinheiro A, Davis RS, Esteves PJ. Matos MC, et al. Int J Mol Sci. 2023 Feb 25;24(5):4531. doi: 10.3390/ijms24054531. Int J Mol Sci. 2023. PMID: 36901962 Free PMC article. - Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation.
Junker F, Gordon J, Qureshi O. Junker F, et al. Front Immunol. 2020 Jul 3;11:1393. doi: 10.3389/fimmu.2020.01393. eCollection 2020. Front Immunol. 2020. PMID: 32719679 Free PMC article. Review. - Fc Receptor-Like 1 as a Promising Target for Immunotherapeutic Interventions of B-Cell-Related Disorders.
Yousefi Z, Sharifzadeh S, Yar-Ahmadi V, Andalib A, Eskandari N. Yousefi Z, et al. Biomark Insights. 2019 Nov 19;14:1177271919882351. doi: 10.1177/1177271919882351. eCollection 2019. Biomark Insights. 2019. PMID: 31798301 Free PMC article. - Pemphigus is associated with KIR3DL2 expression levels and provides evidence that KIR3DL2 may bind HLA-A3 and A11 in vivo.
Augusto DG, O'Connor GM, Lobo-Alves SC, Bass S, Martin MP, Carrington M, McVicar DW, Petzl-Erler ML. Augusto DG, et al. Eur J Immunol. 2015 Jul;45(7):2052-60. doi: 10.1002/eji.201445324. Epub 2015 May 6. Eur J Immunol. 2015. PMID: 25867094 Free PMC article. - Unique ligand-binding property of the human IgM Fc receptor.
Honjo K, Kubagawa Y, Kearney JF, Kubagawa H. Honjo K, et al. J Immunol. 2015 Feb 15;194(4):1975-82. doi: 10.4049/jimmunol.1401866. Epub 2015 Jan 19. J Immunol. 2015. PMID: 25601920 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources