Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells - PubMed (original) (raw)
. 1997 Aug 21;388(6644):782-7.
doi: 10.1038/42030.
Affiliations
- PMID: 9285591
- DOI: 10.1038/42030
Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
M Cella et al. Nature. 1997.
Abstract
Dendritic cells have the remarkable property of presenting any incoming antigen. To do so they must not only capture antigens with high efficiency and broad specificity, but must also maximize their capacity to load class II molecules of the major histocompatibility complex (MHC) with antigenic peptides in order to present a large array of epitopes from different proteins, each at a sufficient copy number. Here we show that formation of peptide-MHC class II complexes is boosted by inflammatory stimuli that induce maturation of dendritic cells. In immature dendritic cells, class II molecules are rapidly internalized and recycled, turning over with a half-life of about 10 hours. Inflammatory stimuli induce a rapid and transient boost of class II synthesis, while the half-life of class II molecules increases to over 100 hours. These coordinated changes result in the rapid accumulation of a large number of long-lived peptide-loaded MHC class II molecules capable of stimulating T cells even after several days. The capacity of dendritic cells to load many antigenic peptides over a short period of initial exposure to inflammatory stimuli could favour presentation of infectious antigens.
Comment in
- Immunology. Inside the gearbox of the dendritic cell.
Watts C. Watts C. Nature. 1997 Aug 21;388(6644):724-5. doi: 10.1038/41900. Nature. 1997. PMID: 9285579 No abstract available.
Similar articles
- T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.
Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL. Boes M, et al. Nature. 2002 Aug 29;418(6901):983-8. doi: 10.1038/nature01004. Nature. 2002. PMID: 12198548 - Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane.
Chow A, Toomre D, Garrett W, Mellman I. Chow A, et al. Nature. 2002 Aug 29;418(6901):988-94. doi: 10.1038/nature01006. Nature. 2002. PMID: 12198549 - Developmental regulation of MHC class II transport in mouse dendritic cells.
Pierre P, Turley SJ, Gatti E, Hull M, Meltzer J, Mirza A, Inaba K, Steinman RM, Mellman I. Pierre P, et al. Nature. 1997 Aug 21;388(6644):787-92. doi: 10.1038/42039. Nature. 1997. PMID: 9285592 - Endosomal sorting of MHC class II determines antigen presentation by dendritic cells.
van Niel G, Wubbolts R, Stoorvogel W. van Niel G, et al. Curr Opin Cell Biol. 2008 Aug;20(4):437-44. doi: 10.1016/j.ceb.2008.05.011. Epub 2008 Jul 5. Curr Opin Cell Biol. 2008. PMID: 18582577 Review. - Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces.
Villadangos JA, Schnorrer P, Wilson NS. Villadangos JA, et al. Immunol Rev. 2005 Oct;207:191-205. doi: 10.1111/j.0105-2896.2005.00317.x. Immunol Rev. 2005. PMID: 16181337 Review.
Cited by
- Ecological principles for the evolution of communication in collective systems.
Staps M, Tarnita CE, Kawakatsu M. Staps M, et al. Proc Biol Sci. 2024 Oct;291(2032):20241562. doi: 10.1098/rspb.2024.1562. Epub 2024 Oct 9. Proc Biol Sci. 2024. PMID: 39381908 - High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists.
Gilmour BC, Corthay A, Øynebråten I. Gilmour BC, et al. NPJ Vaccines. 2024 May 3;9(1):83. doi: 10.1038/s41541-024-00869-1. NPJ Vaccines. 2024. PMID: 38702320 Free PMC article. - Control of adaptive immunity by pattern recognition receptors.
Carroll SL, Pasare C, Barton GM. Carroll SL, et al. Immunity. 2024 Apr 9;57(4):632-648. doi: 10.1016/j.immuni.2024.03.014. Immunity. 2024. PMID: 38599163 Review. - Accelerated onset of diabetes in non-obese diabetic mice fed a refined high-fat diet.
Batdorf HM, Lawes LL, Cassagne GA, Fontenot MS, Harvey IC, Richardson JT, Burk DH, Dupuy SD, Karlstad MD, Salbaum JM, Staszkiewicz J, Beyl R, Ghosh S, Burke SJ, Collier JJ. Batdorf HM, et al. Diabetes Obes Metab. 2024 Jun;26(6):2158-2166. doi: 10.1111/dom.15522. Epub 2024 Mar 4. Diabetes Obes Metab. 2024. PMID: 38433703 - Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice.
Whitaker EE, Mecum NE, Cott RC, Goode DJ. Whitaker EE, et al. PLoS One. 2024 Feb 8;19(2):e0298396. doi: 10.1371/journal.pone.0298396. eCollection 2024. PLoS One. 2024. PMID: 38330029 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials