A gene fusion at a homeobox locus: alterations in leaf shape and implications for morphological evolution - PubMed (original) (raw)
A gene fusion at a homeobox locus: alterations in leaf shape and implications for morphological evolution
J J Chen et al. Plant Cell. 1997 Aug.
Abstract
Compound leaves are seen in many angiosperm genera and are thought to be either fundamentally different from simple leaves or elaborations of simple leaves. The knotted1-like homeobox (knox) genes are known to regulate plant development. When overexpressed in homologous or heterologous species, this family of genes can cause changes in leaf morphology, including excessive leaf compounding in tomato. We describe here an instance of a spontaneously arisen fusion between a gene encoding a metabolic enzyme and a homeodomain protein. We show that the fusion results in overexpression of the homeodomain protein and a change in morphology that approximates the changes caused by overexpression of the same gene under the control of the cauliflower mosaic virus 35S promoter in transgenic plants. Exon-shuffling events can account for the modularity of proteins. If the shuffled exons are associated with altered promoters, changes in gene expression patterns can result. Our results show that gene fusions of this nature can cause changes in expression patterns that lead to altered morphology. We suggest that such phenomena may have played a role in the evolution of form.
Similar articles
- The dominant developmental mutants of tomato, Mouse-ear and Curl, are associated with distinct modes of abnormal transcriptional regulation of a Knotted gene.
Parnis A, Cohen O, Gutfinger T, Hareven D, Zamir D, Lifschitz E. Parnis A, et al. Plant Cell. 1997 Dec;9(12):2143-58. doi: 10.1105/tpc.9.12.2143. Plant Cell. 1997. PMID: 9437860 Free PMC article. - Clausa, a tomato mutant with a wide range of phenotypic perturbations, displays a cell type-dependent expression of the homeobox gene LeT6/TKn2.
Avivi Y, Lev-Yadun S, Morozova N, Libs L, Williams L, Zhao J, Varghese G, Grafi G. Avivi Y, et al. Plant Physiol. 2000 Oct;124(2):541-52. doi: 10.1104/pp.124.2.541. Plant Physiol. 2000. PMID: 11027705 Free PMC article. - Reduced leaf complexity in tomato wiry mutants suggests a role for PHAN and KNOX genes in generating compound leaves.
Kim M, Pham T, Hamidi A, McCormick S, Kuzoff RK, Sinha N. Kim M, et al. Development. 2003 Sep;130(18):4405-15. doi: 10.1242/dev.00655. Development. 2003. PMID: 12900456 - KNOX homeobox genes potentially have similar function in both diploid unicellular and multicellular meristems, but not in haploid meristems.
Sano R, Juárez CM, Hass B, Sakakibara K, Ito M, Banks JA, Hasebe M. Sano R, et al. Evol Dev. 2005 Jan-Feb;7(1):69-78. doi: 10.1111/j.1525-142X.2005.05008.x. Evol Dev. 2005. PMID: 15642091 Review. - Coordination of leaf development via regulation of KNOX1 genes.
Uchida N, Kimura S, Koenig D, Sinha N. Uchida N, et al. J Plant Res. 2010 Jan;123(1):7-14. doi: 10.1007/s10265-009-0248-2. Epub 2009 Jun 9. J Plant Res. 2010. PMID: 19506991 Review.
Cited by
- Leaf form diversity and evolution: a never-ending story in plant biology.
Nakayama H. Nakayama H. J Plant Res. 2024 Jul;137(4):547-560. doi: 10.1007/s10265-024-01541-4. Epub 2024 Apr 9. J Plant Res. 2024. PMID: 38592658 Free PMC article. Review. - Diversity of tomato leaf form provides novel insights into breeding.
Nakayama H, Ichihashi Y, Kimura S. Nakayama H, et al. Breed Sci. 2023 Mar;73(1):76-85. doi: 10.1270/jsbbs.22061. Epub 2023 Jan 20. Breed Sci. 2023. PMID: 37168814 Free PMC article. - The developmental dynamics in cool season legumes with focus on chickpea.
Basu U, Parida SK. Basu U, et al. Plant Mol Biol. 2023 Apr;111(6):473-491. doi: 10.1007/s11103-023-01340-w. Epub 2023 Apr 4. Plant Mol Biol. 2023. PMID: 37016106 Review. - DEFECTIVE EMBRYO AND MERISTEMS1 (DEM1) Is Essential for Cell Proliferation and Cell Differentiation in Tomato.
Matthew L, Reyes MEC, Mann CWG, McDowall AW, Eamens AL, Carroll BJ. Matthew L, et al. Plants (Basel). 2022 Sep 28;11(19):2545. doi: 10.3390/plants11192545. Plants (Basel). 2022. PMID: 36235411 Free PMC article. - Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibrium.
Israeli A, Burko Y, Shleizer-Burko S, Zelnik ID, Sela N, Hajirezaei MR, Fernie AR, Tohge T, Ori N, Bar M. Israeli A, et al. PLoS Genet. 2021 Apr 26;17(4):e1009537. doi: 10.1371/journal.pgen.1009537. eCollection 2021 Apr. PLoS Genet. 2021. PMID: 33901177 Free PMC article.
References
- J Mol Biol. 1986 Jan 20;187(2):169-83 - PubMed
- Nature. 1985 Jun 13-19;315(6020):550-4 - PubMed
- Science. 1995 Dec 22;270(5244):1980-3 - PubMed
- Plant Mol Biol. 1996 Jan;30(1):1-14 - PubMed
- Plant Cell. 1994 Dec;6(12):1877-87 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials