Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells - PubMed (original) (raw)
doi: 10.1007/978-1-4757-9966-8_28.
A M Mommaas, J W Drijfhout, R Jordens, J J Onderwater, D Verwoerd, A A Mulder, A N van der Heiden, T H Ottenhoff, M Cella, A Tulp, J J Neefjes, F Koning
Affiliations
- PMID: 9286356
- DOI: 10.1007/978-1-4757-9966-8_28
Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells
M C Tan et al. Adv Exp Med Biol. 1997.
Abstract
Dendritic cells (DCs) use macropinocytosis and mannose receptor mediated endocytosis for the uptake of exogenous antigens. Here we show that the endocytosis of the mannose receptor and mannosylated antigen is distinct from that of a non-mannosylated antigen. Shortly after internalization, however, both mannosylated and non-mannosylated antigen are found in an MIIC like compartment. The mannose receptor itself does not reach this compartment, and probably releases its ligand in an earlier endosomal structure. Finally, we found that mannosylation of peptides strongly enhanced their potency to stimulate HLA class II-restricted peptide-specific T cell clones. Our results indicate that mannosylation of antigen leads to selective targeting and subsequent superior presentation by DCs which may be useful for vaccine design.
Similar articles
- Mannose receptor-mediated uptake of antigens strongly enhances HLA class II-restricted antigen presentation by cultured dendritic cells.
Tan MC, Mommaas AM, Drijfhout JW, Jordens R, Onderwater JJ, Verwoerd D, Mulder AA, van der Heiden AN, Scheidegger D, Oomen LC, Ottenhoff TH, Tulp A, Neefjes JJ, Koning F. Tan MC, et al. Eur J Immunol. 1997 Sep;27(9):2426-35. doi: 10.1002/eji.1830270942. Eur J Immunol. 1997. PMID: 9341789 - Mannose receptor mediated antigen uptake and presentation in human dendritic cells.
Engering AJ, Cella M, Fluitsma DM, Hoefsmit EC, Lanzavecchia A, Pieters J. Engering AJ, et al. Adv Exp Med Biol. 1997;417:183-7. doi: 10.1007/978-1-4757-9966-8_31. Adv Exp Med Biol. 1997. PMID: 9286359 - Get into the groove! Targeting antigens to MHC class II.
van Bergen J, Ossendorp F, Jordens R, Mommaas AM, Drijfhout JW, Koning F. van Bergen J, et al. Immunol Rev. 1999 Dec;172:87-96. doi: 10.1111/j.1600-065x.1999.tb01358.x. Immunol Rev. 1999. PMID: 10631939 Review. - Mannose receptor-mediated gene delivery into antigen presenting dendritic cells.
Diebold SS, Plank C, Cotten M, Wagner E, Zenke M. Diebold SS, et al. Somat Cell Mol Genet. 2002 Nov;27(1-6):65-74. doi: 10.1023/a:1022975705406. Somat Cell Mol Genet. 2002. PMID: 12774941 Review.
Cited by
- Novel Approaches in the Immunotherapy of Multiple Sclerosis: Cyclization of Myelin Epitope Peptides and Conjugation with Mannan.
Matsoukas JM, Ligielli I, Chasapis CT, Kelaidonis K, Apostolopoulos V, Mavromoustakos T. Matsoukas JM, et al. Brain Sci. 2021 Nov 29;11(12):1583. doi: 10.3390/brainsci11121583. Brain Sci. 2021. PMID: 34942885 Free PMC article. Review. - CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.
Jürgensen HJ, Silva LM, Krigslund O, van Putten S, Madsen DH, Behrendt N, Engelholm LH, Bugge TH. Jürgensen HJ, et al. Matrix Biol Plus. 2019 Mar 19;1:100003. doi: 10.1016/j.mbplus.2019.03.002. eCollection 2019 Feb. Matrix Biol Plus. 2019. PMID: 33543002 Free PMC article. - Macrophage immunoregulatory pathways in tuberculosis.
Rajaram MV, Ni B, Dodd CE, Schlesinger LS. Rajaram MV, et al. Semin Immunol. 2014 Dec;26(6):471-85. doi: 10.1016/j.smim.2014.09.010. Epub 2014 Oct 30. Semin Immunol. 2014. PMID: 25453226 Free PMC article. Review. - M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.
Madsen DH, Leonard D, Masedunskas A, Moyer A, Jürgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS, Brenner DA, Burgdorf S, Engelholm LH, Behrendt N, Holmbeck K, Weigert R, Bugge TH. Madsen DH, et al. J Cell Biol. 2013 Sep 16;202(6):951-66. doi: 10.1083/jcb.201301081. Epub 2013 Sep 9. J Cell Biol. 2013. PMID: 24019537 Free PMC article. - Macrophages in tuberculosis: friend or foe.
Guirado E, Schlesinger LS, Kaplan G. Guirado E, et al. Semin Immunopathol. 2013 Sep;35(5):563-83. doi: 10.1007/s00281-013-0388-2. Epub 2013 Jul 18. Semin Immunopathol. 2013. PMID: 23864058 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Research Materials