A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus - PubMed (original) (raw)

. 1997 Sep 12;277(5332):1656-9.

doi: 10.1126/science.277.5332.1656.

M M Rosenkilde, F Coulin, G Simmons, A H Johnsen, S Alouani, C A Power, H R Lüttichau, J Gerstoft, P R Clapham, I Clark-Lewis, T N Wells, T W Schwartz

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A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus

T N Kledal et al. Science. 1997.

Abstract

Kaposi's sarcoma-associated herpesvirus encodes a chemokine called vMIP-II. This protein displayed a broader spectrum of receptor activities than any mammalian chemokine as it bound with high affinity to a number of both CC and CXC chemokine receptors. Binding of vMIP-II, however, was not associated with the normal, rapid mobilization of calcium from intracellular stores; instead, it blocked calcium mobilization induced by endogenous chemokines. In freshly isolated human monocytes the virally encoded vMIP-II acted as a potent and efficient antagonist of chemotaxis induced by chemokines. Because vMIP-II could inhibit cell entry of human immunodeficiency virus (HIV) mediated through CCR3 and CCR5 as well as CXCR4, this protein may serve as a lead for development of broad-spectrum anti-HIV agents.

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