Crystal structure of RhoA-GDP and its functional implications - PubMed (original) (raw)
Crystal structure of RhoA-GDP and its functional implications
Y Wei et al. Nat Struct Biol. 1997 Sep.
Abstract
RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 A resolution crystal structure of the human RhoA-GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.
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