Interaction of Ras with phosphoinositide 3-kinase gamma - PubMed (original) (raw)
Interaction of Ras with phosphoinositide 3-kinase gamma
I Rubio et al. Biochem J. 1997.
Abstract
Phosphoinositide 3-kinase gamma (PI3Kgamma) can be activated in vitro by both alpha and betagamma subunits of heterotrimeric G-proteins and does not interact with p85, the regulatory subunit of PI3Kalpha. Here we demonstrate the binding of Ras to PI3Kgamma in vitro. An N-terminal region of PI3Kgamma was identified as a binding site for Ras. After co-expression with PI3Kgamma in COS-7 cells, Ras induced only a modest increase in PI3K activity compared with the stimulation of PI3Kalpha by Ras in the same cells.
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