Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines - PubMed (original) (raw)

. 1997 Oct 10;278(5336):290-4.

doi: 10.1126/science.278.5336.290.

Y Endo, P D Collins, Y Takeuchi, J D Reeves, V L Schweickart, M A Siani, T Sasaki, T J Williams, P W Gray, P S Moore, Y Chang, R A Weiss

Affiliations

• PMID: 9323208
• DOI: 10.1126/science.278.5336.290

Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines

C Boshoff et al. Science. 1997.

Abstract

Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.

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Comment in

• Kaposi's sarcoma and protection from HIV dementia.
  Liestael K, Goplen AK, Dunlop O, Bruun JN, Maehlen J. Liestael K, et al. Science. 1998 Apr 17;280(5362):361-2. Science. 1998. PMID: 9575077 No abstract available.

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