Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha - PubMed (original) (raw)

Comparative Study

. 1997 Oct;151(4):1075-83.

Affiliations

• PMID: 9327741
• PMCID: PMC1858048

Comparative Study

Postnatal lung function and morphology in transgenic mice expressing transforming growth factor-alpha

W D Hardie et al. Am J Pathol. 1997 Oct.

Abstract

Developmental changes in lung morphology and physiology during postnatal alveolarization were assessed in transgenic mice expressing transforming growth factor-alpha (TGF-alpha) in pulmonary type II cells under control of the surfactant protein C gene promoter. TGF-alpha transcripts were identified in respiratory epithelial cells at 1 day of age to adulthood. Enlargement of alveolar airspaces and fibrosis were detected as early as 1 week of age, and the increased airspace progressed with advancing age. Specific lung compliance was significantly increased in lungs of transgenic mice by 2 weeks of age and was associated with airflow obstruction. Chronic expression of TGF-alpha in the lungs of newborn transgenic mice caused remodeling of the developing lung during the period of postnatal alveolarization, resulting in markedly enlarged parenchymal airspace, pulmonary fibrosis, and physiological abnormalities including airway obstruction and increased lung compliance.

PubMed Disclaimer

Similar articles

• Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice.
  Korfhagen TR, Swantz RJ, Wert SE, McCarty JM, Kerlakian CB, Glasser SW, Whitsett JA. Korfhagen TR, et al. J Clin Invest. 1994 Apr;93(4):1691-9. doi: 10.1172/JCI117152. J Clin Invest. 1994. PMID: 8163670 Free PMC article.
• Reversal of lung lesions in transgenic transforming growth factor alpha mice by expression of mutant epidermal growth factor receptor.
  Hardie WD, Kerlakian CB, Bruno MD, Huelsman KM, Wert SE, Glasser SW, Whitsett JA, Korfhagen TR. Hardie WD, et al. Am J Respir Cell Mol Biol. 1996 Oct;15(4):499-508. doi: 10.1165/ajrcmb.15.4.8879184. Am J Respir Cell Mol Biol. 1996. PMID: 8879184
• Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha.
  Hardie WD, Piljan-Gentle A, Dunlavy MR, Ikegami M, Korfhagen TR. Hardie WD, et al. Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1088-94. doi: 10.1152/ajplung.2001.281.5.L1088. Am J Physiol Lung Cell Mol Physiol. 2001. PMID: 11597899
• Gene expression in rodent model of environmental lung disease.
  Hoyle GW, Brody AR. Hoyle GW, et al. Ann N Y Acad Sci. 1996 Oct 31;796:162-72. doi: 10.1111/j.1749-6632.1996.tb32577.x. Ann N Y Acad Sci. 1996. PMID: 8906222 Review. No abstract available.
• Dynamic regulation of alveolar morphogenesis in mature lungs.
  Mitzner W. Mitzner W. Am J Physiol Lung Cell Mol Physiol. 2004 May;286(5):L893-5. doi: 10.1152/ajplung.00439.2003. Am J Physiol Lung Cell Mol Physiol. 2004. PMID: 15064236 Review. No abstract available.

Cited by

• Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial-Mesenchymal Transition.
  Zhou Y, Hill C, Yao L, Li J, Hancock D, Downward J, Jones MG, Davies DE, Ewing RM, Skipp P, Wang Y. Zhou Y, et al. Front Mol Biosci. 2021 Mar 19;8:595712. doi: 10.3389/fmolb.2021.595712. eCollection 2021. Front Mol Biosci. 2021. PMID: 33869273 Free PMC article.
• Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk.
  Hill C, Jones MG, Davies DE, Wang Y. Hill C, et al. J Lung Health Dis. 2019 Apr 2;3(2):31-35. J Lung Health Dis. 2019. PMID: 31032489 Free PMC article.
• Attenuation of Allergen-, IL-13-, and TGF-α-induced Lung Fibrosis after the Treatment of rIL-15 in Mice.
  Upparahalli Venkateshaiah S, Niranjan R, Manohar M, Verma AK, Kandikattu HK, Lasky JA, Mishra A. Upparahalli Venkateshaiah S, et al. Am J Respir Cell Mol Biol. 2019 Jul;61(1):97-109. doi: 10.1165/rcmb.2018-0254OC. Am J Respir Cell Mol Biol. 2019. PMID: 30702923 Free PMC article.
• Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.
  Yao L, Conforti F, Hill C, Bell J, Drawater L, Li J, Liu D, Xiong H, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Coldwell M, Yuan X, Ottensmeier CH, Downward J, Collins JE, Ewing RM, Richeldi L, Skipp P, Jones MG, Davies DE, Wang Y. Yao L, et al. Cell Death Differ. 2019 May;26(5):943-957. doi: 10.1038/s41418-018-0175-7. Epub 2018 Jul 26. Cell Death Differ. 2019. PMID: 30050057 Free PMC article.
• Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection.
  Venkataraman T, Coleman CM, Frieman MB. Venkataraman T, et al. J Virol. 2017 May 26;91(12):e00182-17. doi: 10.1128/JVI.00182-17. Print 2017 Jun 15. J Virol. 2017. PMID: 28404843 Free PMC article.

References

1. 1. Am Rev Respir Dis. 1976 Jun;113(6):769-77 - PubMed
2. 1. Pediatr Res. 1996 Mar;39(3):448-55 - PubMed
3. 1. Annu Rev Biochem. 1979;48:193-216 - PubMed
4. 1. Am Rev Respir Dis. 1984 Dec;130(6):1111-7 - PubMed
5. 1. Cell. 1988 Aug 26;54(5):593-5 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)