Integrin signaling: specificity and control of cell survival and cell cycle progression - PubMed (original) (raw)
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Integrin signaling: specificity and control of cell survival and cell cycle progression
F G Giancotti. Curr Opin Cell Biol. 1997 Oct.
Free article
Abstract
Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors.
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