SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase - PubMed (original) (raw)
. 1997 Oct 24;272(43):27178-82.
doi: 10.1074/jbc.272.43.27178.
Affiliations
- PMID: 9341160
- DOI: 10.1074/jbc.272.43.27178
Free article
SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase
K i Ohya et al. J Biol Chem. 1997.
Free article
Abstract
Tec is the prototype of a recently emerging subfamily among nonreceptor type protein-tyrosine kinases and is known to become tyrosine-phosphorylated and activated by a wide range of cytokine stimulations in hematopoietic cells. Although Tec was recently shown to be involved in the cytokine-driven activation mechanism of c-fos transcription, it is yet obscure how Tec relays the signals from cell surface receptors to the nucleus. To identify signaling molecules acting downstream of Tec, we have looked for Tec-interacting proteins (TIPs) by using the yeast two-hybrid system. Here we report the identification and characterization of a novel protein, TIP3, which has been simultaneously identified by other groups as SOCS-1, JAB, or SSI-1. TIP3 carries one Src homology 2 domain with a sequence similarity to that of CIS. In 293 cells, TIP3 associates with Tec and suppresses its kinase activity. Interestingly, TIP3 can also down-regulate the activity of Jak2 but not that of Lyn. We propose that SOCS-1/JAB/SSI-1/TIP3 is a novel type of negative regulator to a subset of protein-tyrosine kinases.
Similar articles
- Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
Narazaki M, Fujimoto M, Matsumoto T, Morita Y, Saito H, Kajita T, Yoshizaki K, Naka T, Kishimoto T. Narazaki M, et al. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13130-4. doi: 10.1073/pnas.95.22.13130. Proc Natl Acad Sci U S A. 1998. PMID: 9789053 Free PMC article. - The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation.
Iwamoto T, Senga T, Naito Y, Matsuda S, Miyake Y, Yoshimura A, Hamaguchi M. Iwamoto T, et al. Oncogene. 2000 Sep 28;19(41):4795-801. doi: 10.1038/sj.onc.1203829. Oncogene. 2000. PMID: 11032030 - The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.
Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A. Yasukawa H, et al. EMBO J. 1999 Mar 1;18(5):1309-20. doi: 10.1093/emboj/18.5.1309. EMBO J. 1999. PMID: 10064597 Free PMC article. - The janus kinase inhibitor, Jab/SOCS-1, is an interferon-gamma inducible gene and determines the sensitivity to interferons.
Sakamoto H, Kinjyo I, Yoshimura A. Sakamoto H, et al. Leuk Lymphoma. 2000 Jun;38(1-2):49-58. doi: 10.3109/10428190009060318. Leuk Lymphoma. 2000. PMID: 10811447 Review. - Negative regulation of cytokine signaling pathways.
Yasukawa H, Sasaki A, Yoshimura A. Yasukawa H, et al. Annu Rev Immunol. 2000;18:143-64. doi: 10.1146/annurev.immunol.18.1.143. Annu Rev Immunol. 2000. PMID: 10837055 Review.
Cited by
- The impact of SOCS1 mutations in diffuse large B-cell lymphoma.
Mellert K, Martin M, Lennerz JK, Lüdeke M, Staiger AM, Kreuz M, Löffler M, Schmitz N, Trümper L, Feller AC, Hartmann S, Hansmann ML, Klapper W, Stein H, Rosenwald A, Ott G, Ziepert M, Möller P. Mellert K, et al. Br J Haematol. 2019 Dec;187(5):627-637. doi: 10.1111/bjh.16147. Epub 2019 Aug 12. Br J Haematol. 2019. PMID: 31407320 Free PMC article. Clinical Trial. - No association between the SOCS-1 -1478CA/del polymorphism and ulcerative colitis in Turkish subjects.
Hartavi M, Nak SG, Oral B, Deligönül A. Hartavi M, et al. Mol Biol Rep. 2014 Oct;41(10):6505-8. doi: 10.1007/s11033-014-3533-7. Epub 2014 Jul 2. Mol Biol Rep. 2014. PMID: 24985978 - The role of suppressors of cytokine signalling in human neoplasms.
Sasi W, Sharma AK, Mokbel K. Sasi W, et al. Mol Biol Int. 2014;2014:630797. doi: 10.1155/2014/630797. Epub 2014 Mar 16. Mol Biol Int. 2014. PMID: 24757565 Free PMC article. Review. - Identification and characterization of suppressor of cytokine signaling 1 (SOCS-1) homologues in teleost fish.
Jin HJ, Xiang LX, Shao JZ. Jin HJ, et al. Immunogenetics. 2007 Aug;59(8):673-86. doi: 10.1007/s00251-007-0232-8. Epub 2007 Jun 14. Immunogenetics. 2007. PMID: 17569039 - Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice.
Inagaki-Ohara K, Sasaki A, Matsuzaki G, Ikeda T, Hotokezaka M, Chijiiwa K, Kubo M, Yoshida H, Nawa Y, Yoshimura A. Inagaki-Ohara K, et al. Gut. 2006 Feb;55(2):212-9. doi: 10.1136/gut.2004.062653. Epub 2005 Aug 24. Gut. 2006. PMID: 16120757 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous