Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator - PubMed (original) (raw)

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

N Kato et al. J Virol. 1997 Nov.

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

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References

1. 1. Cancer Res. 1982 Sep;42(9):3858-63 - PubMed
2. 1. J Mol Biol. 1984 Nov 25;180(1):1-19 - PubMed
3. 1. Nature. 1985 Mar 7-13;314(6006):111-4 - PubMed
4. 1. Science. 1985 Aug 23;229(4715):726-33 - PubMed
5. 1. Virology. 1986 Feb;149(1):10-26 - PubMed

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