Developmental lead exposure causes spatial learning deficits in adult rats - PubMed (original) (raw)
Developmental lead exposure causes spatial learning deficits in adult rats
A C Kuhlmann et al. Neurosci Lett. 1997.
Free article
Abstract
Groups of male rats exposed to lead (Pb) during different developmental periods were tested as adults in a water maze. A highly significant (P < 0.01) impairment in water maze performance was measured in rats exposed to Pb only during gestation and lactation (maternal exposure). At the time of testing (100-106 days old), blood and brain Pb concentrations were at control levels. Significant impairments (P < 0.05) were also present in rats continuously exposed to Pb from conception through adulthood. Post-weaning Pb exposure alone did not result in impaired performance despite significantly elevated blood and brain Pb levels at the time of testing. This study supports the hypothesis that a window of vulnerability to Pb neurotoxicity exists in the developing brain and that Pb exposure can result in long-term cognitive deficits.
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