Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes - PubMed (original) (raw)
Clinical Trial
. 1997 Nov;46(11):1786-91.
doi: 10.2337/diab.46.11.1786.
Affiliations
- PMID: 9356027
- DOI: 10.2337/diab.46.11.1786
Clinical Trial
Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes
R A Anderson et al. Diabetes. 1997 Nov.
Abstract
Chromium is an essential nutrient involved in normal carbohydrate and lipid metabolism. The chromium requirement is postulated to increase with increased glucose intolerance and diabetes. The objective of this study was to test the hypothesis that the elevated intake of supplemental chromium is involved in the control of type 2 diabetes. Individuals being treated for type 2 diabetes (180 men and women) were divided randomly into three groups and supplemented with: 1) placebo, 2) 1.92 micromol (100 microg) Cr as chromium picolinate two times per day, or 3) 9.6 micromol (500 microg) Cr two times per day. Subjects continued to take their normal medications and were instructed not to change their normal eating and living habits. HbA1c values improved significantly after 2 months in the group receiving 19.2 pmol (1,000 microg) Cr per day and was lower in both chromium groups after 4 months (placebo, 8.5 +/- 0.2%; 3.85 micromol Cr, 7.5 +/- 0.2%; 19.2 micromol Cr, 6.6 +/- 0.1%). Fasting glucose was lower in the 19.2-micromol group after 2 and 4 months (4-month values: placebo, 8.8 +/- 0.3 mmol/l; 19.2 micromol Cr, 7.1 +/- 0.2 mmol/l). Two-hour glucose values were also significantly lower for the subjects consuming 19.2 micromol supplemental Cr after both 2 and 4 months (4-month values: placebo, 12.3 +/- 0.4 mmo/l; 19.2 micromol Cr, 10.5 +/- 0.2 mmol/l). Fasting and 2-h insulin values decreased significantly in both groups receiving supplemental chromium after 2 and 4 months. Plasma total cholesterol also decreased after 4 months in the subjects receiving 19.2 micromol/day Cr. These data demonstrate that supplemental chromium had significant beneficial effects on HbA1c, glucose, insulin, and cholesterol variables in subjects with type 2 diabetes. The beneficial effects of chromium in individuals with diabetes were observed at levels higher than the upper limit of the Estimated Safe and Adequate Daily Dietary Intake.
Similar articles
- Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes.
Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V. Sharma S, et al. J Trace Elem Med Biol. 2011 Jul;25(3):149-53. doi: 10.1016/j.jtemb.2011.03.003. Epub 2011 May 12. J Trace Elem Med Biol. 2011. PMID: 21570271 Clinical Trial. - Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.
Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni A. Anderson RA, et al. J Am Coll Nutr. 2001 Jun;20(3):212-8. doi: 10.1080/07315724.2001.10719034. J Am Coll Nutr. 2001. PMID: 11444416 Clinical Trial. - Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes.
Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Albarracin CA, et al. Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51. doi: 10.1002/dmrr.755. Diabetes Metab Res Rev. 2008. PMID: 17506119 Clinical Trial. - Effect of chromium supplementation on glycated hemoglobin and fasting plasma glucose in patients with diabetes mellitus.
Yin RV, Phung OJ. Yin RV, et al. Nutr J. 2015 Feb 13;14:14. doi: 10.1186/1475-2891-14-14. Nutr J. 2015. PMID: 25971249 Free PMC article. Review. - Chromium metabolism and its role in disease processes in man.
Anderson RA. Anderson RA. Clin Physiol Biochem. 1986;4(1):31-41. Clin Physiol Biochem. 1986. PMID: 3514054 Review.
Cited by
- Pancreatic regenerative potential of manuka honey evidenced through pancreatic histology and levels of transcription factors in diabetic rat model.
Iftikhar A, Nausheen R, Khurshid M, Iqbal RK, Muzaffar H, Malik A, Ali Khan A, Batool F, Akhtar S, Yasin A, Anwar H. Iftikhar A, et al. Heliyon. 2023 Sep 9;9(9):e20017. doi: 10.1016/j.heliyon.2023.e20017. eCollection 2023 Sep. Heliyon. 2023. PMID: 37809953 Free PMC article. - Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases.
Rusciano D, Bagnoli P. Rusciano D, et al. Medicina (Kaunas). 2023 Jul 20;59(7):1334. doi: 10.3390/medicina59071334. Medicina (Kaunas). 2023. PMID: 37512145 Free PMC article. Review. - Organic-inorganic hybrid salt and mixed ligand Cr(III) complexes containing the natural flavonoid chrysin: Synthesis, characterization, computational, and biological studies.
Alem MB, Desalegn T, Damena T, Bayle EA, Koobotse MO, Ngwira KJ, Ombito JO, Zachariah M, Demissie TB. Alem MB, et al. Front Chem. 2023 Apr 12;11:1173604. doi: 10.3389/fchem.2023.1173604. eCollection 2023. Front Chem. 2023. PMID: 37123873 Free PMC article. - A Randomized, Placebo-Controlled Crossover Study to Evaluate Postprandial Glucometabolic Effects of Mulberry Leaf Extract, Vitamin D, Chromium, and Fiber in People with Type 2 Diabetes.
Mohamed M, Zagury RL, Bhaskaran K, Neutel J, Mohd Yusof BN, Mooney L, Yeo L, Kirwan BA, Aprikian O, von Eynatten M, Johansen OE. Mohamed M, et al. Diabetes Ther. 2023 Apr;14(4):749-766. doi: 10.1007/s13300-023-01379-4. Epub 2023 Mar 1. Diabetes Ther. 2023. PMID: 36855010 Free PMC article. - How Theoretical Evaluations Can Generate Guidelines for Designing/Engineering Metalloproteins with Desired Metal Affinity and Selectivity.
Dudev T. Dudev T. Molecules. 2022 Dec 28;28(1):249. doi: 10.3390/molecules28010249. Molecules. 2022. PMID: 36615442 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical