The 1996 Merck Frosst Award. The voltage-sensitive release mechanism: a new trigger for cardiac contraction - PubMed (original) (raw)
Review
. 1997 Sep;75(9):1044-57.
doi: 10.1139/cjpp-75-9-1044.
Affiliations
- PMID: 9365812
- DOI: 10.1139/cjpp-75-9-1044
Review
The 1996 Merck Frosst Award. The voltage-sensitive release mechanism: a new trigger for cardiac contraction
S E Howlett et al. Can J Physiol Pharmacol. 1997 Sep.
Abstract
Contraction in mammalian heart is initiated by a rapid rise in intracellular free calcium (Ca2+) triggered by excitation of the sarcolemma. Traditional views of cardiac excitation-contraction coupling have focused on the importance of Ca(2+)-induced Ca2+ release from the sarcoplasmic reticulum as a major source for this increase in Ca2+. Influx of Ca2+, primarily through L-type Ca2+ channels and the sodium-calcium (Na(+)-Ca2+) exchanger, is considered to be the main trigger for Ca(2+)-induced Ca2+ release. However, we recently have discovered a new trigger for excitation-contraction coupling in experiments on isolated ventricular myocytes under voltage clamp conditions. This trigger is a voltage-sensitive release mechanism that initiates release of Ca2+ from the sarcoplasmic reticulum. This article reviews the development of the concept of voltage-activated Ca2+ release in heart and discusses the importance of this discovery to the physiology, pathophysiology, and pharmacology of cardiac contraction.
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