Relationship between the genomic organization and the overlapping embryonic expression patterns of the zebrafish dlx genes - PubMed (original) (raw)
Comparative Study
. 1997 Nov 1;45(3):580-90.
doi: 10.1006/geno.1997.4978.
Affiliations
- PMID: 9367683
- DOI: 10.1006/geno.1997.4978
Comparative Study
Relationship between the genomic organization and the overlapping embryonic expression patterns of the zebrafish dlx genes
D L Ellies et al. Genomics. 1997.
Abstract
To understand the relationship between the expression and the genomic organization of the zebrafish dlx genes, we have determined the genomic structure of the dlx2 and dlx4 loci. This led to the identification of the zebrafish dlx1 and dlx6 genes, which are closely linked to dlx2 and dlx4, respectively. Therefore, the inverted convergent configuration of Dlx genes is conserved among vertebrates. Analysis of the expression patterns of dlx1 and dlx6 showed striking similarities to those of dlx2 and dlx4, respectively, the genes to which they are linked. Furthermore, the expression patterns of dlx3 and dlx7, which likely constitute a third pair of convergently transcribed genes, are indistinguishable. Thus, the overlapping expression patterns of linked Dlx genes during embryonic development suggest that they share cis-acting sequences that control their spatiotemporal expression. The evolutionary conservation of the genomic organization and combinatorial expression of Dlx genes in distantly related vertebrates suggest tight control mechanisms that are essential for their function during development.
Copyright 1997 Academic Press.
Similar articles
- Cross-interactions between two members of the Dlx family of homeobox-containing genes during zebrafish development.
Zerucha T, Muller JP, Chartrand N, Ekker M. Zerucha T, et al. Biochem Cell Biol. 1997;75(5):613-22. Biochem Cell Biol. 1997. PMID: 9551183 - Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters.
Ghanem N, Jarinova O, Amores A, Long Q, Hatch G, Park BK, Rubenstein JL, Ekker M. Ghanem N, et al. Genome Res. 2003 Apr;13(4):533-43. doi: 10.1101/gr.716103. Genome Res. 2003. PMID: 12670995 Free PMC article. - Dlx3 is expressed in the ventral forebrain of chicken embryos: implications for the evolution of the Dlx gene family.
Zhu H, Bendall AJ. Zhu H, et al. Int J Dev Biol. 2006;50(1):71-5. doi: 10.1387/ijdb.052087hz. Int J Dev Biol. 2006. PMID: 16323080 - Distal-less-related homeobox genes of vertebrates: evolution, function, and regulation.
Zerucha T, Ekker M. Zerucha T, et al. Biochem Cell Biol. 2000;78(5):593-601. Biochem Cell Biol. 2000. PMID: 11103950 Review. - Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development.
Depew MJ, Simpson CA, Morasso M, Rubenstein JL. Depew MJ, et al. J Anat. 2005 Nov;207(5):501-61. doi: 10.1111/j.1469-7580.2005.00487.x. J Anat. 2005. PMID: 16313391 Free PMC article. Review.
Cited by
- The Gq/11 family of Gα subunits is necessary and sufficient for lower jaw development.
Kanai SM, Garcia CR, Augustus MR, Sharafeldeen SA, Brooks EP, Sucharov J, Lencer ES, Nichols JT, Clouthier DE. Kanai SM, et al. bioRxiv [Preprint]. 2024 Sep 19:2024.09.17.611698. doi: 10.1101/2024.09.17.611698. bioRxiv. 2024. PMID: 39345358 Free PMC article. Preprint. - lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.
Sun L, Ping L, Gao R, Zhang B, Chen X. Sun L, et al. Genes (Basel). 2023 Jun 28;14(7):1371. doi: 10.3390/genes14071371. Genes (Basel). 2023. PMID: 37510276 Free PMC article. - DLX Genes in the Development and Maintenance of the Vertebrate Skeleton: Implications for Human Pathologies.
Levi G, Narboux-Nême N, Cohen-Solal M. Levi G, et al. Cells. 2022 Oct 18;11(20):3277. doi: 10.3390/cells11203277. Cells. 2022. PMID: 36291143 Free PMC article. Review. - Increased Sociability in Mice Lacking Intergenic Dlx Enhancers.
Fazel Darbandi S, Esau C, Lesage-Pelletier C, Monis S, Poitras L, Yu M, Perin S, Hatch G, Ekker M. Fazel Darbandi S, et al. Front Neurosci. 2021 Oct 4;15:718948. doi: 10.3389/fnins.2021.718948. eCollection 2021. Front Neurosci. 2021. PMID: 34671237 Free PMC article. - DLX Genes: Roles in Development and Cancer.
Tan Y, Testa JR. Tan Y, et al. Cancers (Basel). 2021 Jun 15;13(12):3005. doi: 10.3390/cancers13123005. Cancers (Basel). 2021. PMID: 34203994 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases