IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling - PubMed (original) (raw)
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
M Muzio et al. Science. 1997.
Abstract
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
Republished in
- Pillars article: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997. 278: 1612-1615.
Muzio M, Ni J, Feng P, Dixit VM. Muzio M, et al. J Immunol. 2013 Jan 1;190(1):16-9. J Immunol. 2013. PMID: 23264670 No abstract available.
Similar articles
- IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z. Wesche H, et al. J Biol Chem. 1999 Jul 2;274(27):19403-10. doi: 10.1074/jbc.274.27.19403. J Biol Chem. 1999. PMID: 10383454 - Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1.
Jefferies C, Bowie A, Brady G, Cooke EL, Li X, O'Neill LA. Jefferies C, et al. Mol Cell Biol. 2001 Jul;21(14):4544-52. doi: 10.1128/MCB.21.14.4544-4552.2001. Mol Cell Biol. 2001. PMID: 11416133 Free PMC article. - MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway CA Jr. Medzhitov R, et al. Mol Cell. 1998 Aug;2(2):253-8. doi: 10.1016/s1097-2765(00)80136-7. Mol Cell. 1998. PMID: 9734363 - NF-kappa B activation by tumor necrosis factor and interleukin-1.
Cao Z, Tanaka M, Regnier C, Rothe M, Yamit-hezi A, Woronicz JD, Fuentes ME, Durnin MH, Dalrymple SA, Goeddel DV. Cao Z, et al. Cold Spring Harb Symp Quant Biol. 1999;64:473-83. doi: 10.1101/sqb.1999.64.473. Cold Spring Harb Symp Quant Biol. 1999. PMID: 11232324 Review. No abstract available. - Modulation of Toll-interleukin 1 receptor mediated signaling.
Li X, Qin J. Li X, et al. J Mol Med (Berl). 2005 Apr;83(4):258-66. doi: 10.1007/s00109-004-0622-4. Epub 2005 Jan 21. J Mol Med (Berl). 2005. PMID: 15662540 Review.
Cited by
- IL-1 receptor-associated kinase 3 (IRAK3) in lung adenocarcinoma predicts prognosis and immunotherapy resistance: involvement of multiple inflammation-related pathways.
Zhou Y, Rao W, Li Z, Guo W, Shao F, Zhang Z, Zhang H, Liu T, Li Z, Tan F, Xue Q, Gao S, He J. Zhou Y, et al. Transl Lung Cancer Res. 2024 Sep 30;13(9):2139-2161. doi: 10.21037/tlcr-24-391. Epub 2024 Sep 12. Transl Lung Cancer Res. 2024. PMID: 39430338 Free PMC article. - The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration.
Goumenaki P, Günther S, Kikhi K, Looso M, Marín-Juez R, Stainier DYR. Goumenaki P, et al. Nat Cardiovasc Res. 2024 Sep;3(9):1158-1176. doi: 10.1038/s44161-024-00538-5. Epub 2024 Sep 13. Nat Cardiovasc Res. 2024. PMID: 39271818 Free PMC article. - Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways.
Rughetti A, Bharti S, Savai R, Barmpoutsi S, Weigert A, Atre R, Siddiqi F, Sharma R, Khabiya R, Hirani N, Baig MS. Rughetti A, et al. Future Sci OA. 2024 Dec 31;10(1):2387961. doi: 10.1080/20565623.2024.2387961. Epub 2024 Sep 9. Future Sci OA. 2024. PMID: 39248050 Free PMC article. Review. - Targeting Myeloid Differentiation Primary Response Protein 88 (MyD88) and Galectin-3 to Develop Broad-Spectrum Host-Mediated Therapeutics against SARS-CoV-2.
Saikh KU, Anam K, Sultana H, Ahmed R, Kumar S, Srinivasan S, Ahmed H. Saikh KU, et al. Int J Mol Sci. 2024 Aug 1;25(15):8421. doi: 10.3390/ijms25158421. Int J Mol Sci. 2024. PMID: 39125989 Free PMC article. Review. - The Interplay of TLR-NFκB Signalling Pathway and Functional Immune-Related Enzymes in the Inflammatory Response of Ciona robusta.
Bisanti L, La Corte C, Dara M, Bertini F, Vizioli J, Parisi MG, Cammarata M, Parrinello D. Bisanti L, et al. Animals (Basel). 2024 Jul 25;14(15):2169. doi: 10.3390/ani14152169. Animals (Basel). 2024. PMID: 39123695 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous