Comparison of tethering and rolling of eosinophils and neutrophils through selectins and P-selectin glycoprotein ligand-1 - PubMed (original) (raw)
Comparative Study
. 1997 Nov 1;159(9):4555-65.
Affiliations
- PMID: 9379057
Comparative Study
Comparison of tethering and rolling of eosinophils and neutrophils through selectins and P-selectin glycoprotein ligand-1
K D Patel et al. J Immunol. 1997.
Abstract
We compared the abilities of selectins and the selectin ligand, P-selectin glycoprotein ligand-1 (PSGL-1), to support tethering and rolling of eosinophils and neutrophils under physiologic flow conditions. Eosinophils and neutrophils accumulated on P-selectin at similar site densities and rolled at similar velocities, but fewer eosinophils than neutrophils accumulated at any P-selectin density. Compared with neutrophils, few eosinophils accumulated on E-selectin except at high densities, and those cells that did accumulate rolled faster than neutrophils. Examination of the mechanisms for accumulation revealed that eosinophils and neutrophils formed similar numbers of primary tethers to P-selectin, whereas eosinophils formed fewer primary tethers to E-selectin than did neutrophils. Compared with neutrophils, adherent eosinophils also supported fewer leukocyte-leukocyte interactions, resulting in diminished secondary tethers to either P- or E-selectin. Studies with mAbs to L-selectin and PSGL-1 demonstrated that neither cell type used L-selectin to form primary tethers to P- or E-selectin. Both eosinophils and neutrophils used the NH2 terminus of PSGL-1 to form primary tethers to P-selectin, but not to E-selectin. Both cell types used L-selectin and PSGL-1 to promote leukocyte-leukocyte interactions and secondary tethers to P- or E-selectin. However, eosinophils developed significantly fewer secondary interactions, probably because they express less L-selectin than do neutrophils.
Similar articles
- Expression and function of P-selectin glycoprotein ligand 1 (CD162) on human basophils.
Taylor ML, Brummet ME, Hudson SA, Miura K, Bochner BS. Taylor ML, et al. J Allergy Clin Immunol. 2000 Nov;106(5):918-24. doi: 10.1067/mai.2000.110230. J Allergy Clin Immunol. 2000. PMID: 11080715 - PSGL-1 function in immunity and steady state homeostasis.
Carlow DA, Gossens K, Naus S, Veerman KM, Seo W, Ziltener HJ. Carlow DA, et al. Immunol Rev. 2009 Jul;230(1):75-96. doi: 10.1111/j.1600-065X.2009.00797.x. Immunol Rev. 2009. PMID: 19594630 Review.
Cited by
- CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.
Immler R, Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, Napoli M, Schmidt S, Margraf A, Pruenster M, Rohwedder I, Lange-Sperandio B, Mall MA, de Jong R, Ohnmacht C, Bernhagen J, Voehringer D, Marth JD, Frommhold D, Sperandio M. Immler R, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2319057121. doi: 10.1073/pnas.2319057121. Epub 2024 Apr 30. Proc Natl Acad Sci U S A. 2024. PMID: 38687790 - PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy.
DeRogatis JM, Viramontes KM, Neubert EN, Tinoco R. DeRogatis JM, et al. Front Immunol. 2021 Feb 23;12:636238. doi: 10.3389/fimmu.2021.636238. eCollection 2021. Front Immunol. 2021. PMID: 33708224 Free PMC article. Review. - An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis.
Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. Korde A, et al. J Allergy Clin Immunol. 2020 Feb;145(2):550-562. doi: 10.1016/j.jaci.2019.10.031. J Allergy Clin Immunol. 2020. PMID: 32035607 Free PMC article. - Rapid and label-free microfluidic neutrophil purification and phenotyping in diabetes mellitus.
Hou HW, Petchakup C, Tay HM, Tam ZY, Dalan R, Chew DE, Li KH, Boehm BO. Hou HW, et al. Sci Rep. 2016 Jul 6;6:29410. doi: 10.1038/srep29410. Sci Rep. 2016. PMID: 27381673 Free PMC article. - P-selectin glycoprotein ligand-1 deficiency augments G-CSF induced myeloid cell mobilization.
Miszti-Blasius K, Felszeghy S, Kiss C, Benkő I, Géresi K, Megyeri A, Hevessy Z, Kappelmayer J. Miszti-Blasius K, et al. Naunyn Schmiedebergs Arch Pharmacol. 2014 Feb;387(2):109-18. doi: 10.1007/s00210-013-0913-9. Epub 2013 Oct 5. Naunyn Schmiedebergs Arch Pharmacol. 2014. PMID: 24091681
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources