Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent - PubMed (original) (raw)
Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent
A Sahota et al. Ann Neurol. 1997 Oct.
Abstract
As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE epsilon4 allele frequency was significantly increased in AD patients compared with controls. The age-adjusted odds ratio (OR) for AD in epsilon4 homozygotes was 4.83 (95% confidence interval [CI], 1.71-13.64) compared with the epsilon3/epsilon3 genotype, but the OR for AD with the epsilon3/epsilon4 genotype did not reach significance (1.20; 95% CI, 0.58-2.45). These findings suggest that the association between ApoE epsilon4 and AD is weaker in African Americans than in whites.
Similar articles
- The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.
Tang MX, Stern Y, Marder K, Bell K, Gurland B, Lantigua R, Andrews H, Feng L, Tycko B, Mayeux R. Tang MX, et al. JAMA. 1998 Mar 11;279(10):751-5. doi: 10.1001/jama.279.10.751. JAMA. 1998. PMID: 9508150 - Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. Farrer LA, et al. JAMA. 1997 Oct 22-29;278(16):1349-56. JAMA. 1997. PMID: 9343467 - Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.
Graff-Radford NR, Green RC, Go RC, Hutton ML, Edeki T, Bachman D, Adamson JL, Griffith P, Willis FB, Williams M, Hipps Y, Haines JL, Cupples LA, Farrer LA. Graff-Radford NR, et al. Arch Neurol. 2002 Apr;59(4):594-600. doi: 10.1001/archneur.59.4.594. Arch Neurol. 2002. PMID: 11939894 - Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis.
Agarwal R, Tripathi CB. Agarwal R, et al. Am J Alzheimers Dis Other Demen. 2014 Nov;29(7):575-82. doi: 10.1177/1533317514531443. Am J Alzheimers Dis Other Demen. 2014. PMID: 25551132 Free PMC article. Review. - The Neurobiology and Age-Related Prevalence of the ε4 Allele of Apolipoprotein E in Alzheimer's Disease Cohorts.
Heffernan AL, Chidgey C, Peng P, Masters CL, Roberts BR. Heffernan AL, et al. J Mol Neurosci. 2016 Nov;60(3):316-324. doi: 10.1007/s12031-016-0804-x. Epub 2016 Aug 6. J Mol Neurosci. 2016. PMID: 27498201 Free PMC article. Review.
Cited by
- Apolipoprotein epsilon4 allele frequency in young Africans of Ugandan descent versus African Americans.
Willis F, Graff-Radford N, Pinto M, Lawson L, Adamson J, Epstein D, Parfitt F, Hutton M, O'Brien PC. Willis F, et al. J Natl Med Assoc. 2003 Jan;95(1):71-6. J Natl Med Assoc. 2003. PMID: 12656452 Free PMC article. - Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.
Fullerton SM, Clark AG, Weiss KM, Nickerson DA, Taylor SL, Stengârd JH, Salomaa V, Vartiainen E, Perola M, Boerwinkle E, Sing CF. Fullerton SM, et al. Am J Hum Genet. 2000 Oct;67(4):881-900. doi: 10.1086/303070. Epub 2000 Sep 13. Am J Hum Genet. 2000. PMID: 10986041 Free PMC article. - Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics.
Blue EE, Horimoto ARVR, Mukherjee S, Wijsman EM, Thornton TA. Blue EE, et al. Alzheimers Dement. 2019 Dec;15(12):1524-1532. doi: 10.1016/j.jalz.2019.07.016. Epub 2019 Oct 9. Alzheimers Dement. 2019. PMID: 31606368 Free PMC article. - Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds.
Griswold AJ, Celis K, Bussies PL, Rajabli F, Whitehead PL, Hamilton-Nelson KL, Beecham GW, Dykxhoorn DM, Nuytemans K, Wang L, Gardner OK, Dorfsman DA, Bigio EH, Mesulam MM, Weintraub S, Geula C, Gearing M, McGrath-Martinez E, Dalgard CL, Scott WK, Haines JL, Pericak-Vance MA, Young JI, Vance JM. Griswold AJ, et al. Alzheimers Dement. 2021 Jul;17(7):1179-1188. doi: 10.1002/alz.12287. Epub 2021 Feb 1. Alzheimers Dement. 2021. PMID: 33522086 Free PMC article. - Association of apolipoprotein E genotype and Alzheimer disease in African Americans.
Murrell JR, Price B, Lane KA, Baiyewu O, Gureje O, Ogunniyi A, Unverzagt FW, Smith-Gamble V, Gao S, Hendrie HC, Hall KS. Murrell JR, et al. Arch Neurol. 2006 Mar;63(3):431-4. doi: 10.1001/archneur.63.3.431. Arch Neurol. 2006. PMID: 16533971 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous