Brain-derived neurotrophic factor is reduced in Alzheimer's disease - PubMed (original) (raw)

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease.

Babygirija R, Han JH, Sonsalla MM, Matoska R, Calubag MF, Green CL, Tobon A, Yeh CY, Vertein D, Schlorf S, Illiano J, Liu Y, Grunow I, Rigby MJ, Puglielli L, Harris DA, Denu JM, Lamming DW. Babygirija R, et al. bioRxiv [Preprint]. 2024 Sep 24:2024.09.19.613904. doi: 10.1101/2024.09.19.613904. bioRxiv. 2024. PMID: 39386545 Free PMC article. Preprint.

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease.

Fonseca-Gomes J, Costa-Coelho T, Ferreira-Manso M, Inteiro-Oliveira S, Vaz SH, Alemãn-Serrano N, Atalaia-Barbacena H, Ribeiro-Rodrigues L, Ramalho RM, Pinto R, Vicente Miranda H, Tanqueiro SR, de Almeida-Borlido C, Ramalho MJ, Miranda-Lourenço C, Belo RF, Ferreira CB, Neves V, Rombo DM, Viais R, Martins IC, Jerónimo-Santos A, Caetano A, Manso N, Mäkinen P, Marttinen M, Takalo M, Bremang M, Pike I, Haapasalo A, Loureiro JA, Pereira MC, Santos NC, Outeiro TF, Castanho MARB, Fernandes A, Hiltunen M, Duarte CB, Castrén E, de Mendonça A, Sebastião AM, Rodrigues TM, Diógenes MJ. Fonseca-Gomes J, et al. Mol Ther. 2024 Oct 2;32(10):3372-3401. doi: 10.1016/j.ymthe.2024.08.022. Epub 2024 Aug 27. Mol Ther. 2024. PMID: 39205389

Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes.

Leventoux N, Morimoto S, Ishikawa M, Nakamura S, Ozawa F, Kobayashi R, Watanabe H, Supakul S, Okamoto S, Zhou Z, Kobayashi H, Kato C, Hirokawa Y, Aiba I, Takahashi S, Shibata S, Takao M, Yoshida M, Endo F, Yamanaka K, Kokubo Y, Okano H. Leventoux N, et al. Acta Neuropathol. 2024 May 15;147(1):84. doi: 10.1007/s00401-024-02734-w. Acta Neuropathol. 2024. PMID: 38750212