Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells - PubMed (original) (raw)
. 1997 Nov 17;240(2):329-34.
doi: 10.1006/bbrc.1997.7666.
Affiliations
- PMID: 9388477
- DOI: 10.1006/bbrc.1997.7666
Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells
K Sato et al. Biochem Biophys Res Commun. 1997.
Abstract
Exogenous sphingosine 1-phosphate (S1P), like lysophosphatidic acid (LPA), induced neurite retraction or cell rounding in differentiated PC12 cells. The lysosphingolipid-induced shape change was detected at as low as 1 nM; however, a significant accumulation of intracellular S1P was not detected until 1 microM S1P was applied. Moreover, although exogenous sphingosine caused a significant increase in intracellular S1P by sphingosine kinase-catalyzed phosphorylation, the effect on the shape change was marginal. Exposure of the cells to the immobilized S1P in which the lipid was covalently linked to a glass carrier also resulted in the shape change. These results suggest that the exogenous S1P-induced shape change does not require uptake of the lipid into the cells but possibly requires interaction with a cell surface receptor in the neuronal cells.
Similar articles
- Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells.
Tamama K, Kon J, Sato K, Tomura H, Kuwabara A, Kimura T, Kanda T, Ohta H, Ui M, Kobayashi I, Okajima F. Tamama K, et al. Biochem J. 2001 Jan 1;353(Pt 1):139-146. Biochem J. 2001. PMID: 11115407 Free PMC article. - Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors.
Bassi R, Anelli V, Giussani P, Tettamanti G, Viani P, Riboni L. Bassi R, et al. Glia. 2006 Apr 15;53(6):621-30. doi: 10.1002/glia.20324. Glia. 2006. PMID: 16470810 - Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes.
Anelli V, Bassi R, Tettamanti G, Viani P, Riboni L. Anelli V, et al. J Neurochem. 2005 Mar;92(5):1204-15. doi: 10.1111/j.1471-4159.2004.02955.x. J Neurochem. 2005. PMID: 15715670 - Roles of extracellular and intracellular sphingosine 1-phosphate in cell migration.
Yu H, Okada T, Kobayashi M, Abo-Elmatty DM, Jahangeer S, Nakamura S. Yu H, et al. Genes Cells. 2009 May;14(5):597-605. doi: 10.1111/j.1365-2443.2009.01295.x. Epub 2009 Apr 15. Genes Cells. 2009. PMID: 19371379 - New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets.
Huwiler A, Pfeilschifter J. Huwiler A, et al. Biochem Pharmacol. 2008 May 15;75(10):1893-900. doi: 10.1016/j.bcp.2007.12.018. Epub 2008 Jan 5. Biochem Pharmacol. 2008. PMID: 18321471 Review.
Cited by
- Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.
Jaillard C, Harrison S, Stankoff B, Aigrot MS, Calver AR, Duddy G, Walsh FS, Pangalos MN, Arimura N, Kaibuchi K, Zalc B, Lubetzki C. Jaillard C, et al. J Neurosci. 2005 Feb 9;25(6):1459-69. doi: 10.1523/JNEUROSCI.4645-04.2005. J Neurosci. 2005. PMID: 15703400 Free PMC article. - Human neural progenitors express functional lysophospholipid receptors that regulate cell growth and morphology.
Hurst JH, Mumaw J, Machacek DW, Sturkie C, Callihan P, Stice SL, Hooks SB. Hurst JH, et al. BMC Neurosci. 2008 Dec 11;9:118. doi: 10.1186/1471-2202-9-118. BMC Neurosci. 2008. PMID: 19077254 Free PMC article. - Distribution of sphingosine kinase activity and mRNA in rodent brain.
Blondeau N, Lai Y, Tyndall S, Popolo M, Topalkara K, Pru JK, Zhang L, Kim H, Liao JK, Ding K, Waeber C. Blondeau N, et al. J Neurochem. 2007 Oct;103(2):509-17. doi: 10.1111/j.1471-4159.2007.04755.x. Epub 2007 Jul 10. J Neurochem. 2007. PMID: 17623044 Free PMC article. - Lysophospholipid receptors in the nervous system.
Toman RE, Spiegel S. Toman RE, et al. Neurochem Res. 2002 Aug;27(7-8):619-27. doi: 10.1023/a:1020219915922. Neurochem Res. 2002. PMID: 12374197 Review. - The Role of Astrocytes in Multiple Sclerosis.
Ponath G, Park C, Pitt D. Ponath G, et al. Front Immunol. 2018 Feb 19;9:217. doi: 10.3389/fimmu.2018.00217. eCollection 2018. Front Immunol. 2018. PMID: 29515568 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous