Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis - PubMed (original) (raw)
Comparative Study
Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis
B Cortet et al. Ann Rheum Dis. 1997 Oct.
Abstract
Objective: To compare the results of pulmonary function tests (PFTs) and high resolution computed tomography (HRCT) of the lungs in rheumatoid arthritis (RA) patients.
Methods: Sixty eight patients (54 women, 14 men) fulfilling the revised criteria for RA were consecutively included in a transversal prospective study. Their mean age was 58.8 years (range: 35-82) and the mean duration of the disease was 12 years (range: 5-16). Rheumatoid factor was positive in 52 patients (76.5%). Fifty two patients (76.5%) were lifelong non-smokers. Detailed medical and drug histories were obtained. PFTs comprised spirometry and gas transfer measurements. Results for PFTs were expressed as percentage of predicted values for each individual adjusted for age, sex, and height. HRCT was undertaken with a Siemens Somatom Plus.
Results: A significant decrease of FEV1/ FVC, FEF25%, FEF50%, FEF75%, FEF25-75%, and TLCO was observed (p < 0.05) and 13.2% of the patients had a small airways involvement defined by a decrease of FEF25-75% below 1.64 SD. The most frequent HRCT findings were: bronchiectasis (30.5%), pulmonary nodules (28%), and air trapping (25%). The patients with small airways involvement had a high frequency of recurrent bronchitis (75% v 34%, p = 0.05) and bronchiectasis (71% v 23%, p = 0.019). The patients with bronchiectasis were characterised by low values of FEV1, FVC, FEF25-75%, and TLCO (p < 0.01), a high prevalence of small airways involvement (29% v 5%, p = 0.019), and a low prevalence of HLA DQA1 *0501 allele (14% v 33%, p < 0.05).
Conclusion: This study suggests a significant association between small airways involvement on PFTs and bronchiectasis on HRCT in unselected RA patients.
Similar articles
- Airways involvement in rheumatoid arthritis: clinical, functional, and HRCT findings.
Perez T, Remy-Jardin M, Cortet B. Perez T, et al. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1658-65. doi: 10.1164/ajrccm.157.5.9710018. Am J Respir Crit Care Med. 1998. PMID: 9603152 - Respiratory symptoms in rheumatoid arthritis: relation between high resolution CT findings and functional impairment.
Terasaki H, Fujimoto K, Hayabuchi N, Ogoh Y, Fukuda T, Müller NL. Terasaki H, et al. Radiat Med. 2004 May-Jun;22(3):179-85. Radiat Med. 2004. PMID: 15287534 - Bronchial reactivity and airflow obstruction in rheumatoid arthritis.
Hassan WU, Keaney NP, Holland CD, Kelly CA. Hassan WU, et al. Ann Rheum Dis. 1994 Aug;53(8):511-4. doi: 10.1136/ard.53.8.511. Ann Rheum Dis. 1994. PMID: 7944635 Free PMC article. - [Bronchiectasis and rheumatoid arthritis. Incidence and etiopathogenic aspects. Review of the literature].
Despaux J, Toussirot E, Wendling D. Despaux J, et al. Rev Med Interne. 1997;18(2):144-52. doi: 10.1016/s0248-8663(97)84681-4. Rev Med Interne. 1997. PMID: 9092034 Review. French. - Coexistence of bronchiectasis and rheumatoid arthritis: revisited.
Wilczynska MM, Condliffe AM, McKeon DJ. Wilczynska MM, et al. Respir Care. 2013 Apr;58(4):694-701. doi: 10.4187/respcare.01857. Respir Care. 2013. PMID: 22782500 Review.
Cited by
- Pulmonary involvement in lifelong non-smoking patients with rheumatoid arthritis and ankylosing spondylitis without respiratory symptoms.
Ayhan-Ardic FF, Oken O, Yorgancioglu ZR, Ustun N, Gokharman FD. Ayhan-Ardic FF, et al. Clin Rheumatol. 2006 Mar;25(2):213-8. doi: 10.1007/s10067-005-1158-x. Epub 2005 Aug 10. Clin Rheumatol. 2006. PMID: 16091838 - Pleural effusion associated with rheumatoid arthritis: what cell predominance to anticipate?
Avnon LS, Abu-Shakra M, Flusser D, Heimer D, Sion-Vardy N. Avnon LS, et al. Rheumatol Int. 2007 Aug;27(10):919-25. doi: 10.1007/s00296-007-0322-9. Epub 2007 Feb 9. Rheumatol Int. 2007. PMID: 17294192 Review. - Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 5. Connective Tissue Disease Associated Interstitial Lung Disease.
Koo SM, Kim SY, Choi SM, Lee HK; Korean Interstitial Lung Diseases Study Group. Koo SM, et al. Tuberc Respir Dis (Seoul). 2019 Oct;82(4):285-297. doi: 10.4046/trd.2019.0009. Epub 2019 May 31. Tuberc Respir Dis (Seoul). 2019. PMID: 31172701 Free PMC article. Review. - Pulmonary involvement in rheumatoid arthritis: evaluation by radiography and spirometry.
Kawassaki AM, Pereira DA, Kay FU, Laurindo IM, Carvalho CR, Kairalla RA. Kawassaki AM, et al. J Bras Pneumol. 2015 Jul-Aug;41(4):331-42. doi: 10.1590/S1806-37132015000004518. J Bras Pneumol. 2015. PMID: 26398753 Free PMC article. - Interstitial Lung Disease in Elderly Rheumatoid Arthritis Patients.
Messina R, Guggino G, Benfante A, Scichilone N. Messina R, et al. Drugs Aging. 2020 Jan;37(1):11-18. doi: 10.1007/s40266-019-00727-z. Drugs Aging. 2020. PMID: 31773418 Review.
References
- Rheumatol Int. 1994;14(3):115-8 - PubMed
- Ann Rheum Dis. 1994 Aug;53(8):511-4 - PubMed
- Ann Rheum Dis. 1995 Apr;54(4):308-10 - PubMed
- Appl Theor Electrophor. 1995;5(1):7-13 - PubMed
- Ann Rheum Dis. 1995 Oct;54(10):815-9 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials