Brain injury in the premature infant. Neuropathology, clinical aspects, pathogenesis, and prevention - PubMed (original) (raw)
Affiliations
- PMID: 9394861
Review
Brain injury in the premature infant. Neuropathology, clinical aspects, pathogenesis, and prevention
J J Volpe. Clin Perinatol. 1997 Sep.
Abstract
There are two principal lesions that underlie brain injury and the neurologic manifestations in the premature infant: periventricular hemorrhagic infarction and periventricular leukomalacia. Both of these lesions may be potentially preventable: periventricular hemorrhagic infarction by preventing germinal matrix-IVH, and periventricular leukomalacia by detecting impaired cerebrovascular regulation with near-infrared spectroscopy, preventing the impaired cerebral blood flow and interrupting the cascade to oligodendroglial cell death, perhaps by such agents as free-radical scavengers. Prenatal magnesium sulfate also may be valuable. The greatest progress toward prevention has been made regarding periventricular hemorrhagic infarction, but the advent of new technologies, especially near-infrared spectroscopy, and of new insights into the cellular basis for oligodendroglial vulnerability provide hope for prevention of periventricular leukomalacia.
Similar articles
- Brain injury in the premature infant--from pathogenesis to prevention.
Volpe JJ. Volpe JJ. Brain Dev. 1997 Dec;19(8):519-34. doi: 10.1016/s0387-7604(97)00078-8. Brain Dev. 1997. PMID: 9440796 Review. - Neurologic outcome of prematurity.
Volpe JJ. Volpe JJ. Arch Neurol. 1998 Mar;55(3):297-300. doi: 10.1001/archneur.55.3.297. Arch Neurol. 1998. PMID: 9520002 Review. - Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesis.
Volpe JJ. Volpe JJ. Semin Pediatr Neurol. 1998 Sep;5(3):135-51. doi: 10.1016/s1071-9091(98)80030-2. Semin Pediatr Neurol. 1998. PMID: 9777673 Review. - Neurobiology of periventricular leukomalacia in the premature infant.
Volpe JJ. Volpe JJ. Pediatr Res. 2001 Nov;50(5):553-62. doi: 10.1203/00006450-200111000-00003. Pediatr Res. 2001. PMID: 11641446 Review. - Relationship between periventricular hemorrhage, leukomalacia and brainstem lesions in prematurely born infants.
Takashima S, Mito T, Houdou S, Ando Y. Takashima S, et al. Brain Dev. 1989;11(2):121-4. doi: 10.1016/s0387-7604(89)80080-4. Brain Dev. 1989. PMID: 2712235
Cited by
- Magnetic resonance imaging in preterm infants.
Arthur R. Arthur R. Pediatr Radiol. 2006 Jul;36(7):593-607. doi: 10.1007/s00247-006-0154-x. Epub 2006 May 19. Pediatr Radiol. 2006. PMID: 16770664 Review. - The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate.
McCrea HJ, Ment LR. McCrea HJ, et al. Clin Perinatol. 2008 Dec;35(4):777-92, vii. doi: 10.1016/j.clp.2008.07.014. Clin Perinatol. 2008. PMID: 19026340 Free PMC article. Review. - Neuroprotective and Regenerative Effects of Growth Hormone (GH) in the Embryonic Chicken Cerebral Pallium Exposed to Hypoxic-Ischemic (HI) Injury.
Olivares-Hernández JD, Carranza M, Balderas-Márquez JE, Epardo D, Baltazar-Lara R, Ávila-Mendoza J, Martínez-Moreno CG, Luna M, Arámburo C. Olivares-Hernández JD, et al. Int J Mol Sci. 2022 Aug 13;23(16):9054. doi: 10.3390/ijms23169054. Int J Mol Sci. 2022. PMID: 36012320 Free PMC article. - Cerebral blood flow and oxygenation in ovine fetus: responses to superimposed hypoxia at both low and high altitude.
Pena JP, Tomimatsu T, Hatran DP, McGill LL, Longo LD. Pena JP, et al. J Physiol. 2007 Jan 1;578(Pt 1):359-70. doi: 10.1113/jphysiol.2006.119925. Epub 2006 Oct 26. J Physiol. 2007. PMID: 17068100 Free PMC article. - Neuroprotection in the newborn infant.
Gonzalez FF, Ferriero DM. Gonzalez FF, et al. Clin Perinatol. 2009 Dec;36(4):859-80, vii. doi: 10.1016/j.clp.2009.07.013. Clin Perinatol. 2009. PMID: 19944839 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical