Acetylcholine and associative memory in the piriform cortex - PubMed (original) (raw)

Review

Acetylcholine and associative memory in the piriform cortex

E Barkai et al. Mol Neurobiol. 1997 Aug.

Abstract

The significance of cholinergic modulation for associative memory performance in the piriform cortex was examined in a study combining cellular neurophysiology in brain slices with realistic biophysical network simulations. Three different physiological effects of acetylcholine were identified at the single-cell level: suppression of neuronal adaptation, suppression of synaptic transmission in the intrinsic fibers layer, and activity-dependent increase in synaptic strength. Biophysical simulations show how these three effects are joined together to enhance learning and recall performance of the cortical network. Furthermore, our data suggest that activity-dependent synaptic decay during learning is a crucial factor in determining learning capability of the cortical network. Accordingly, it is predicted that acetylcholine should also enhance long-term depression in the piriform cortex.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Brain Res. 1989 Mar 13;482(1):194-7 - PubMed
    1. J Neurophysiol. 1988 May;59(5):1352-76 - PubMed
    1. J Neurophysiol. 1988 Feb;59(2):450-67 - PubMed
    1. Science. 1974 Aug 30;185(4153):796-8 - PubMed
    1. J Neurosci. 1995 Oct;15(10):6592-604 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources