A CTD function linking transcription to splicing - PubMed (original) (raw)

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A CTD function linking transcription to splicing

J L Corden et al. Trends Biochem Sci. 1997 Nov.

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Abstract

Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.

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