The peripheral T-cell pool: regulation by non-antigen induced proliferation? - PubMed (original) (raw)
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The peripheral T-cell pool: regulation by non-antigen induced proliferation?
E B Bell et al. Semin Immunol. 1997 Dec.
Abstract
Despite continuous perturbations, the recirculating lymphocyte pool remains relatively constant. Expansion of the pool is compensated for by cell loss. When the T-cell pool is in deficit, either from a congenital defect or an acquired immunodeficiency, T-cell numbers are restored by extrathymic division-a response that occurs without deliberate provocation. We have considered how the recirculating pool may be stably maintained and how a T-cell deficit might be restored to equilibrium. Recent evidence suggests that depleted T-cell compartments are replenished by CD4 T-cell proliferation in the absence of specific antigen, a response that occurs without engaging the T-cell receptor.
Copyright 1997 Academic Press Limited.
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