Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers - PubMed (original) (raw)
Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers
A C Kim et al. Genomics. 1997.
Abstract
LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. They were first identified as cysteine-rich motifs found in the three proteins Lin-11, Isl-1, and Mec-3. LIM proteins frequently contain DNA-binding homeodomains, allowing these proteins to activate transcription. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. Limatin is a novel LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. Here we report the murine and human chromosomal localizations of limatin (LIMAB1). Limatin was mapped to mouse Chromosome 19 by restriction fragment length polymorphism analysis and to human chromosome region 10q25 by fluorescence in situ hybridization. Radiation hybrid mapping placed LIMAB1 in a 37-cR interval between markers D10S554 and D10S2390. Interestingly, 10q25 is a region of frequent loss of heterozygosity in human tumors, thus identifying limatin as a candidate tumor suppressor gene.
Similar articles
- Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19.
Edelhoff S, Ayer DE, Zervos AS, Steingrímsson E, Jenkins NA, Copeland NG, Eisenman RN, Brent R, Disteche CM. Edelhoff S, et al. Oncogene. 1994 Feb;9(2):665-8. Oncogene. 1994. PMID: 8290278 - Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3.
Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y. Karim MA, et al. Genomics. 1996 Jan 15;31(2):167-76. doi: 10.1006/geno.1996.0028. Genomics. 1996. PMID: 8824798 - Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression.
Lutchman M, Pack S, Kim AC, Azim A, Emmert-Buck M, van Huffel C, Zhuang Z, Chishti AH. Lutchman M, et al. Cancer Genet Cytogenet. 1999 Nov;115(1):65-9. doi: 10.1016/s0165-4608(99)00081-3. Cancer Genet Cytogenet. 1999. PMID: 10565303 - A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3.
Kiss H, Kedra D, Yang Y, Kost-Alimova M, Kiss C, O'Brien KP, Fransson I, Klein G, Imreh S, Dumanski JP. Kiss H, et al. Hum Genet. 1999 Dec;105(6):552-9. doi: 10.1007/s004399900188. Hum Genet. 1999. PMID: 10647888 - Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.
Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH. Rasheed BK, et al. Oncogene. 1995 Jun 1;10(11):2243-6. Oncogene. 1995. PMID: 7784070
Cited by
- Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker.
Liu D, Wang X, Liu Y, Li C, Zhang Z, Lv P. Liu D, et al. Dis Markers. 2022 Dec 20;2022:9516808. doi: 10.1155/2022/9516808. eCollection 2022. Dis Markers. 2022. PMID: 36583064 Free PMC article. - XB130-A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis.
Bai XH, Cho HR, Moodley S, Liu M. Bai XH, et al. Scientifica (Cairo). 2014;2014:903014. doi: 10.1155/2014/903014. Epub 2014 Jun 5. Scientifica (Cairo). 2014. PMID: 24995146 Free PMC article. Review. - There is more than one way to model an elephant. Experiment-driven modeling of the actin cytoskeleton.
Ditlev JA, Mayer BJ, Loew LM. Ditlev JA, et al. Biophys J. 2013 Feb 5;104(3):520-32. doi: 10.1016/j.bpj.2012.12.044. Biophys J. 2013. PMID: 23442903 Free PMC article. Review. - The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9).
Chen L, Brown JW, Mok YF, Hatters DM, McKnight CJ. Chen L, et al. J Biol Chem. 2013 Mar 22;288(12):8313-8320. doi: 10.1074/jbc.M112.438861. Epub 2013 Jan 25. J Biol Chem. 2013. PMID: 23355471 Free PMC article. - Genetic loci that control the size of laser-induced choroidal neovascularization.
Nakai K, Rogers MS, Baba T, Funakoshi T, Birsner AE, Luyindula DS, D'Amato RJ. Nakai K, et al. FASEB J. 2009 Jul;23(7):2235-43. doi: 10.1096/fj.08-124321. Epub 2009 Feb 23. FASEB J. 2009. PMID: 19237505 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous