Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens - PubMed (original) (raw)

Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens

B C Herold et al. Antimicrob Agents Chemother. 1997 Dec.

Abstract

Heparan sulfate (HS) serves as a receptor for adherence of herpes simplex viruses, Chlamydia trachomatis, Neisseria gonorrhoeae, and, indirectly, human immunodeficiency virus. Using primary human culture systems, we identified sulfated carbohydrate compounds that resemble HS and competitively inhibit infection by these pathogens. These compounds are candidates for intravaginal formulations for the prevention of sexually transmitted diseases.

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