Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary - PubMed (original) (raw)

Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

A Sakurada et al. Jpn J Cancer Res. 1997 Nov.

Abstract

In the present study, we searched for genetic alterations of the entire coding region of PTEN/MMAC1, a recently isolated candidate tumor suppressor gene, in 178 specimens from Japanese patients with various malignant tumors by the polymerase chain reaction-single strand conformation polymorphism method. The samples consisted of 11 glioblastoma multiformes (GBMs), 14 astrocytomas, 47 breast cancers, 25 non-small cell lung cancers, 9 small cell lung cancers, 8 pancreatic cancers, 24 renal cell carcinomas, 20 ovarian cancers, and 20 metastatic lung tumors from various organs. Only one somatic frameshift mutation at codon 319 was observed in one (9%) of eleven GBMs. Our results suggest that mutation of the PTEN/MMAC1 gene does not play a major role in carcinogenesis, at least in the tumor types from Japanese patients analyzed in this study.

PubMed Disclaimer

References

1. ) Walker , A. E. , Robins , M. and Weinfeld , F. D.Epidemiology of brain tumors: the national survey of intracranial neoplasms . Neurology , 35 , 219 – 226 ( 1985. ). - PubMed
1. ) Kuratsu , J. and Ushio , Y.Epidemiological study of primary intracranial tumors: a regional survey in Kumamoto Prefecture in the southern part of Japan . J. Neurosurg. , 84 , 946 – 950 ( 1996. ). - PubMed
1. ) Ekstrand , A. J. , James , C. D. , Cavenee , W. K. , Seliger , B. , Pettersson , R. F. and Collins , V. P.Genes for epidermal growth factor receptor, transforming growth factor α, and epidermal growth factor and their expression in human gliomas in vivo . Cancer Res. , 51 , 2164 – 2172 ( 1991. ). - PubMed
1. ) Louis , D. N. and Gusella , J. F.A tiger behind many doors: multiple genetic pathways to malignant glioma . Trends Genet. , 11 , 412 – 415 ( 1995. ). - PubMed
1. ) Li , J. , Yen , C. , Liaw , D. , Podsypanina , K. , Bose , S. , Wang , S. I. , Puc , J. , Miliaresis , C. , Rdgers , L. , Mccombie , R. , Bingner , S. H. , Giovanella , B. C. , Ittmann , M. , Tycko , B. , Hibshoosh , H. , Wigler , M. H. and Parsons , R.PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer . Science , 275 , 1943 – 1947 ( 1997. ). - PubMed

Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary - PubMed (original) (raw)