Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation? - PubMed (original) (raw)
Does base composition help predispose the complementarity-determining regions of antibodies to hypermutation?
E A Padlan. Mol Immunol. 1997 Aug.
Abstract
A survey of the base usage in genes coding for human antibodies reveals that more (A+T) and less (C+G) are found in the segments coding for the complementarity-determining regions, while the opposite is true for the segments coding for framework and constant regions. The possibility that this bias in base usage may contribute to hypermutation is explored.
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