A bacterial RNA that functions as both a tRNA and an mRNA - PubMed (original) (raw)

Review

A bacterial RNA that functions as both a tRNA and an mRNA

A Muto et al. Trends Biochem Sci. 1998 Jan.

Abstract

Bacterial tmRNA (transfer-messenger RNA, also known as 10Sa RNA) contains a tRNA-like structure in the 5'- and 3'-end sequences and an internal reading frame encoding a 'tag' peptide. The dual function of this molecule as both a tRNA and an mRNA facilitates a trans-translation reaction, in which a ribosome can switch between translation of a truncated mRNA and the tmRNA's tag sequence. The result is a chimeric protein with the tag peptide attached to the C-terminus of the truncated peptide.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources