Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1 - PubMed (original) (raw)

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

M J Lee et al. Science. 1998.

Erratum in

• Erratum for the Report "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1" by M.-J. Lee et al.
  [No authors listed] [No authors listed] Science. 2024 Aug 2;385(6708):eadr9977. doi: 10.1126/science.adr9977. Epub 2024 Aug 1. Science. 2024. PMID: 39088640 No abstract available.

Abstract

The sphingolipid metabolite sphingosine-1-phosphate (SPP) has been implicated as a second messenger in cell proliferation and survival. However, many of its biological effects are due to binding to unidentified receptors on the cell surface. SPP activated the heterotrimeric guanine nucleotide binding protein (G protein)-coupled orphan receptor EDG-1, originally cloned as Endothelial Differentiation Gene-1. EDG-1 bound SPP with high affinity (dissociation constant = 8.1 nM) and high specificity. Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.

PubMed Disclaimer

Similar articles

• Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.
  Hla T, Lee MJ, Ancellin N, Thangada S, Liu CH, Kluk M, Chae SS, Wu MT. Hla T, et al. Ann N Y Acad Sci. 2000 Apr;905:16-24. doi: 10.1111/j.1749-6632.2000.tb06534.x. Ann N Y Acad Sci. 2000. PMID: 10818438 Review.
• Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.
  Spiegel S. Spiegel S. Ann N Y Acad Sci. 2000 Apr;905:54-60. doi: 10.1111/j.1749-6632.2000.tb06537.x. Ann N Y Acad Sci. 2000. PMID: 10818441 Review.
• Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.
  Van Brocklyn JR, Tu Z, Edsall LC, Schmidt RR, Spiegel S. Van Brocklyn JR, et al. J Biol Chem. 1999 Feb 19;274(8):4626-32. doi: 10.1074/jbc.274.8.4626. J Biol Chem. 1999. PMID: 9988698
• Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival.
  Van Brocklyn JR, Lee MJ, Menzeleev R, Olivera A, Edsall L, Cuvillier O, Thomas DM, Coopman PJ, Thangada S, Liu CH, Hla T, Spiegel S. Van Brocklyn JR, et al. J Cell Biol. 1998 Jul 13;142(1):229-40. doi: 10.1083/jcb.142.1.229. J Cell Biol. 1998. PMID: 9660876 Free PMC article.

Cited by

• Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.
  Zhang G, Yang L, Kim GS, Ryan K, Lu S, O'Donnell RK, Spokes K, Shapiro N, Aird WC, Kluk MJ, Yano K, Sanchez T. Zhang G, et al. Blood. 2013 Jul 18;122(3):443-55. doi: 10.1182/blood-2012-11-467191. Epub 2013 May 30. Blood. 2013. PMID: 23723450 Free PMC article.
• Association of Sphingosine-1-phosphate (S1P)/S1P Receptor-1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma.
  Rodriguez AM, Graef AJ, LeVine DN, Cohen IR, Modiano JF, Kim JH. Rodriguez AM, et al. J Vet Intern Med. 2015 Jul-Aug;29(4):1088-97. doi: 10.1111/jvim.13570. Epub 2015 Jun 25. J Vet Intern Med. 2015. PMID: 26118793 Free PMC article.
• Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling.
  Szepanowski F, Derksen A, Steiner I, Meyer Zu Hörste G, Daldrup T, Hartung HP, Kieseier BC. Szepanowski F, et al. J Neuroinflammation. 2016 Jun 10;13(1):143. doi: 10.1186/s12974-016-0612-9. J Neuroinflammation. 2016. PMID: 27283020 Free PMC article.
• Metabolic Regulation of Apoptosis in Cancer.
  Matsuura K, Canfield K, Feng W, Kurokawa M. Matsuura K, et al. Int Rev Cell Mol Biol. 2016;327:43-87. doi: 10.1016/bs.ircmb.2016.06.006. Epub 2016 Jul 30. Int Rev Cell Mol Biol. 2016. PMID: 27692180 Free PMC article. Review.
• Attenuating the Effects of Novel COVID-19 (SARS-CoV-2) Infection-Induced Cytokine Storm and the Implications.
  Rowaiye AB, Okpalefe OA, Onuh Adejoke O, Ogidigo JO, Hannah Oladipo O, Ogu AC, Oli AN, Olofinase S, Onyekwere O, Rabiu Abubakar A, Jahan D, Islam S, Dutta S, Haque M. Rowaiye AB, et al. J Inflamm Res. 2021 Apr 16;14:1487-1510. doi: 10.2147/JIR.S301784. eCollection 2021. J Inflamm Res. 2021. PMID: 33889008 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal