Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus - PubMed (original) (raw)
Affiliations
- PMID: 9491329
Case Reports
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
B Singh et al. Genes Chromosomes Cancer. 1998 Feb.
Abstract
Cowden disease, a dominantly inherited syndrome characterized by a variety of proliferative lesions and predisposition to breast and thyroid cancer, has recently been linked to the polymorphic marker D10S215 on chromosome segment 10q23. Loss of heterozygosity in prostate cancer is linked to the same marker, whereas loss of heterozygosity in glioblastoma, endometrial cancer, and other malignancies also localizes to this region. Most recently, a putative tumor suppressor gene (PTEN/MMAC1) has been identified in the region between D10S215 and an adjacent, more telomeric marker (D10S541) and was found to be altered in breast cancers, prostate cancers, and glioblastomas. We examined 22 invasive breast cancers for loss of heterozygosity in the 10q23 region and found loss in 41% (9/22). There were two distinct regions of loss, including one near the D10S541 marker, with an approximately equal frequency of deletion in each. The observed pattern of deletion is consistent with the presence of a tumor suppressor gene between D10S215 and D10S541. Most of the poorly differentiated carcinomas in the case collection showed loss of heterozygosity in the region near D10S215, suggesting that this loss correlates with a poor prognosis.
Similar articles
- Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas.
Marsh DJ, Zheng Z, Zedenius J, Kremer H, Padberg GW, Larsson C, Longy M, Eng C. Marsh DJ, et al. Cancer Res. 1997 Feb 1;57(3):500-3. Cancer Res. 1997. PMID: 9012481 - Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions.
Kerangueven F, Eisinger F, Noguchi T, Allione F, Wargniez V, Eng C, Padberg G, Theillet C, Jacquemier J, Longy M, Sobol H, Birnbaum D. Kerangueven F, et al. Oncogene. 1997 Jan 23;14(3):339-47. doi: 10.1038/sj.onc.1200818. Oncogene. 1997. PMID: 9018120 - Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread.
Tsuda H, Callen DF, Fukutomi T, Nakamura Y, Hirohashi S. Tsuda H, et al. Cancer Res. 1994 Jan 15;54(2):513-7. Cancer Res. 1994. PMID: 8275489 - Cowden disease or multiple hamartoma syndrome--cutaneous clue to internal malignancy.
Fistarol SK, Anliker MD, Itin PH. Fistarol SK, et al. Eur J Dermatol. 2002 Sep-Oct;12(5):411-21. Eur J Dermatol. 2002. PMID: 12370126 Review. - Cowden syndrome (multiple hamartoma syndrome).
Mallory SB. Mallory SB. Dermatol Clin. 1995 Jan;13(1):27-31. Dermatol Clin. 1995. PMID: 7712647 Review.
Cited by
- Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M. Kwabi-Addo B, et al. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11563-8. doi: 10.1073/pnas.201167798. Epub 2001 Sep 11. Proc Natl Acad Sci U S A. 2001. PMID: 11553783 Free PMC article. - PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer.
Fujita T, Doihara H, Kawasaki K, Takabatake D, Takahashi H, Washio K, Tsukuda K, Ogasawara Y, Shimizu N. Fujita T, et al. Br J Cancer. 2006 Jan 30;94(2):247-52. doi: 10.1038/sj.bjc.6602926. Br J Cancer. 2006. PMID: 16404430 Free PMC article. - PTEN Genetic and Epigenetic Alterations Define Distinct Subgroups in North Indian Breast Cancer Patients.
Kazim Z, Wahabi K, Perwez A, Lal P, Rizvi MA. Kazim Z, et al. Asian Pac J Cancer Prev. 2019 Jan 25;20(1):269-276. doi: 10.31557/APJCP.2019.20.1.269. Asian Pac J Cancer Prev. 2019. PMID: 30678449 Free PMC article. - Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.
Feilotter HE, Coulon V, McVeigh JL, Boag AH, Dorion-Bonnet F, Duboué B, Latham WC, Eng C, Mulligan LM, Longy M. Feilotter HE, et al. Br J Cancer. 1999 Feb;79(5-6):718-23. doi: 10.1038/sj.bjc.6690115. Br J Cancer. 1999. PMID: 10070859 Free PMC article. - The impact of PTEN tumor suppressor gene on acquiring resistance to tamoxifen treatment in breast cancer patients.
Tanic N, Milovanovic Z, Tanic N, Dzodic R, Juranic Z, Susnjar S, Plesinac-Karapandzic V, Tatic S, Dramicanin T, Davidovic R, Dimitrijevic B. Tanic N, et al. Cancer Biol Ther. 2012 Oct;13(12):1165-74. doi: 10.4161/cbt.21346. Epub 2012 Aug 15. Cancer Biol Ther. 2012. PMID: 22892847 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials