SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling - PubMed (original) (raw)
SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling
N Guex et al. Electrophoresis. 1997 Dec.
Abstract
Comparative protein modeling is increasingly gaining interest since it is of great assistance during the rational design of mutagenesis experiments. The availability of this method, and the resulting models, has however been restricted by the availability of expensive computer hardware and software. To overcome these limitations, we have developed an environment for comparative protein modeling that consists of SWISS-MODEL, a server for automated comparative protein modeling and of the SWISS-PdbViewer, a sequence to structure workbench. The Swiss-PdbViewer not only acts as a client for SWISS-MODEL, but also provides a large selection of structure analysis and display tools. In addition, we provide the SWISS-MODEL Repository, a database containing more than 3500 automatically generated protein models. By making such tools freely available to the scientific community, we hope to increase the use of protein structures and models in the process of experiment design.
Similar articles
- Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective.
Guex N, Peitsch MC, Schwede T. Guex N, et al. Electrophoresis. 2009 Jun;30 Suppl 1:S162-73. doi: 10.1002/elps.200900140. Electrophoresis. 2009. PMID: 19517507 - Large scale protein modelling and model repository.
Peitsch MC. Peitsch MC. Proc Int Conf Intell Syst Mol Biol. 1997;5:234-6. Proc Int Conf Intell Syst Mol Biol. 1997. PMID: 9322042 - SWISS-MODEL: An automated protein homology-modeling server.
Schwede T, Kopp J, Guex N, Peitsch MC. Schwede T, et al. Nucleic Acids Res. 2003 Jul 1;31(13):3381-5. doi: 10.1093/nar/gkg520. Nucleic Acids Res. 2003. PMID: 12824332 Free PMC article. - Protein structure computing in the genomic era.
Schwede T, Diemand A, Guex N, Peitsch MC. Schwede T, et al. Res Microbiol. 2000 Mar;151(2):107-12. doi: 10.1016/s0923-2508(00)00121-2. Res Microbiol. 2000. PMID: 10865955 Review. - Automated modelling of the transmembrane region of G-protein coupled receptor by Swiss-model.
Peitsch MC, Herzyk P, Wells TN, Hubbard RE. Peitsch MC, et al. Recept Channels. 1996;4(3):161-4. Recept Channels. 1996. PMID: 9014239 Review.
Cited by
- Punctuated Loci on Chromosome IV Determine Natural Variation in Orsay Virus Susceptibility of Caenorhabditis elegans Strains Bristol N2 and Hawaiian CB4856.
Sterken MG, van Sluijs L, Wang YA, Ritmahan W, Gultom ML, Riksen JAG, Volkers RJM, Snoek LB, Pijlman GP, Kammenga JE. Sterken MG, et al. J Virol. 2021 May 24;95(12):e02430-20. doi: 10.1128/JVI.02430-20. Print 2021 May 24. J Virol. 2021. PMID: 33827942 Free PMC article. - In silico characterization and homology modeling of cytosolic APX gene predicts novel glycine residue modulating waterlogging stress response in pigeon pea.
Tyagi A, Sharma S, Srivastava H, Singh NK, Gaikwad K. Tyagi A, et al. PeerJ. 2021 May 12;9:e10888. doi: 10.7717/peerj.10888. eCollection 2021. PeerJ. 2021. PMID: 34026340 Free PMC article. - Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests.
Yamaoka Y, Miyakawa K, Jeremiah SS, Funabashi R, Okudela K, Kikuchi S, Katada J, Wada A, Takei T, Nishi M, Shimizu K, Ozawa H, Usuku S, Kawakami C, Tanaka N, Morita T, Hayashi H, Mitsui H, Suzuki K, Aizawa D, Yoshimura Y, Miyazaki T, Yamazaki E, Suzuki T, Kimura H, Shimizu H, Okabe N, Hasegawa H, Ryo A. Yamaoka Y, et al. Cell Rep Med. 2021 Jun 15;2(6):100311. doi: 10.1016/j.xcrm.2021.100311. Epub 2021 May 16. Cell Rep Med. 2021. PMID: 34027498 Free PMC article. - Structural and enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus.
Hiblot J, Gotthard G, Chabriere E, Elias M. Hiblot J, et al. PLoS One. 2012;7(10):e47028. doi: 10.1371/journal.pone.0047028. Epub 2012 Oct 10. PLoS One. 2012. PMID: 23071703 Free PMC article. - Building a virtual ligand screening pipeline using free software: a survey.
Glaab E. Glaab E. Brief Bioinform. 2016 Mar;17(2):352-66. doi: 10.1093/bib/bbv037. Epub 2015 Jun 20. Brief Bioinform. 2016. PMID: 26094053 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources