Cerebellar mutant mice and chimeras revisited - PubMed (original) (raw)
Affiliations
- PMID: 9509517
Review
Cerebellar mutant mice and chimeras revisited
R J Mullen et al. Perspect Dev Neurobiol. 1997.
Abstract
Neurological mutant mice have yielded an early and continuously rich resource for studying the role of genes in the developing cerebellum. Experimentally produced chimeric mice, containing mixtures of genetically normal and mutant cells, provided a means of deducing the primary site of gene action and studying cell interactions in these mutant cerebella. Recently, three mutant genes, reeler, weaver, and staggerer, have been cloned and their gene products identified. These three genes have been examined earlier by the chimera technology. Here, we review the chimera studies in the light of what we now know to be the products of these mutant genes.
Similar articles
- Cerebellar histogenesis as seen in identified cells of normal-reeler mouse chimeras.
Yoshiki A, Kusakabe M. Yoshiki A, et al. Int J Dev Biol. 1998 Jul;42(5):695-700. Int J Dev Biol. 1998. PMID: 9712524 - Expression of glial antigens C1 and M1 in developing and adult neurologically mutant mice.
Sommer I, Schachner M. Sommer I, et al. J Supramol Struct Cell Biochem. 1981;16(1):53-74. doi: 10.1002/jsscb.1981.380160106. J Supramol Struct Cell Biochem. 1981. PMID: 7028999 - Observations on the cerebellum of normal-reeler mutant mouse chimera.
Terashima T, Inoue K, Inoue Y, Yokoyama M, Mikoshiba K. Terashima T, et al. J Comp Neurol. 1986 Oct 8;252(2):264-78. doi: 10.1002/cne.902520209. J Comp Neurol. 1986. PMID: 3782509 - The chick/quail chimeric system: a model for early cerebellar development.
Hallonet M, Alvarado-Mallart RM. Hallonet M, et al. Perspect Dev Neurobiol. 1997;5(1):17-31. Perspect Dev Neurobiol. 1997. PMID: 9509515 Review. - Neurotrophins and cerebellar development.
Lindholm D, Hamnér S, Zirrgiebel U. Lindholm D, et al. Perspect Dev Neurobiol. 1997;5(1):83-94. Perspect Dev Neurobiol. 1997. PMID: 9509520 Review.
Cited by
- Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma.
Emmenegger BA, Hwang EI, Moore C, Markant SL, Brun SN, Dutton JW, Read TA, Fogarty MP, Singh AR, Durden DL, Yang C, McKeehan WL, Wechsler-Reya RJ. Emmenegger BA, et al. Oncogene. 2013 Aug 29;32(35):4181-8. doi: 10.1038/onc.2012.440. Epub 2012 Oct 8. Oncogene. 2013. PMID: 23045271 Free PMC article. - Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum.
Kubera C, Hernandez AL, Heng V, Bordey A. Kubera C, et al. Neuroscience. 2012 Sep 6;219:271-9. doi: 10.1016/j.neuroscience.2012.05.064. Epub 2012 Jun 4. Neuroscience. 2012. PMID: 22677205 Free PMC article. - Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.
Eckardt S, McLaughlin KJ, Willenbring H. Eckardt S, et al. Cell Cycle. 2011 Jul 1;10(13):2091-9. doi: 10.4161/cc.10.13.16360. Epub 2011 Jul 1. Cell Cycle. 2011. PMID: 21606677 Free PMC article. Review. - Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.
Barakat MT, Humke EW, Scott MP. Barakat MT, et al. Trends Mol Med. 2010 Aug;16(8):337-48. doi: 10.1016/j.molmed.2010.05.003. Epub 2010 Jun 16. Trends Mol Med. 2010. PMID: 20696410 Free PMC article. Review. - Altered development of the brain after focal herpesvirus infection of the central nervous system.
Koontz T, Bralic M, Tomac J, Pernjak-Pugel E, Bantug G, Jonjic S, Britt WJ. Koontz T, et al. J Exp Med. 2008 Feb 18;205(2):423-35. doi: 10.1084/jem.20071489. Epub 2008 Feb 11. J Exp Med. 2008. PMID: 18268036 Free PMC article.