Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA - PubMed (original) (raw)
. 1998 Mar 5;392(6671):42-8.
doi: 10.1038/32100.
Affiliations
- PMID: 9510247
- DOI: 10.1038/32100
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
L Chen et al. Nature. 1998.
Abstract
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene promoter, shows an extended interface between NFAT and AP-1, facilitated by the bending of Fos and DNA. The tight association of the three proteins on DNA creates a continuous groove for the recognition of 15 base pairs.
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