Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders - PubMed (original) (raw)
Meta-Analysis
. 1998 Feb 7;81(1):58-63.
Affiliations
- PMID: 9514589
Meta-Analysis
Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders
R A Furlong et al. Am J Med Genet. 1998.
Abstract
The serotonin transporter is a compelling candidate gene to examine in bipolar and unipolar affective disorder, since drugs that specifically inhibit the serotonin transporter can successfully treat depression. Previous association studies of a VNTR polymorphism in intron 2 and a functional insertion/deletion polymorphism in the promoter of this gene have produced conflicting results. The present study examined allele and genotype frequencies for both of these polymorphisms and resulting haplotypes in 87 English Caucasian bipolar patients, 125 English Caucasian unipolar affective disorder patients, and 174 controls. No significant associations were detected when these unipolar or bipolar cases were compared either separately or as a pooled "affective disorder" group to the controls. A meta-analysis of over 1,400 individuals of European Caucasian origin was then performed, comprising 772 controls, 375 bipolar and 299 unipolar patients for the VNTR polymorphism, and 739 controls, 392 bipolar and 275 unipolar patients for the promoter polymorphism. A significant association of promoter allele 2 was shown with bipolar (estimated odds ratio 1.21; 95% confidence interval 1.00-1.45), unipolar (OR 1.23; 95% CI 1.01-1.42), and combined bipolar + unipolar groups (OR 1.22; 95% CI 1.04-1.42). There was no demonstrable allelic association of the VNTR polymorphism with affective disorder: for the combined bipolar + unipolar group the odds ratios for VNTR alleles 9 and 10, compared with the common allele 12 were 1.05 (95% CI 0.56-1.95) and 0.90 (95% CI 0.77-1.05). These results suggest that the promoter allele 2, which has previously been shown to result in lower levels of serotonin transporter transcription, may be associated with affective disorder risk.
Similar articles
- A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders.
Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Müller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP. Collier DA, et al. Mol Psychiatry. 1996 Dec;1(6):453-60. Mol Psychiatry. 1996. PMID: 9154246 - Association analysis of 5HT transporter gene in bipolar disorder in the Indian population.
Saleem Q, Ganesh S, Vijaykumar M, Reddy YC, Brahmachari SK, Jain S. Saleem Q, et al. Am J Med Genet. 2000 Apr 3;96(2):170-2. Am J Med Genet. 2000. PMID: 10893491 - A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder.
Willeit M, Praschak-Rieder N, Neumeister A, Zill P, Leisch F, Stastny J, Hilger E, Thierry N, Konstantinidis A, Winkler D, Fuchs K, Sieghart W, Aschauer H, Ackenheil M, Bondy B, Kasper S. Willeit M, et al. Mol Psychiatry. 2003 Nov;8(11):942-6. doi: 10.1038/sj.mp.4001392. Mol Psychiatry. 2003. PMID: 14593433 - Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis.
Cho HJ, Meira-Lima I, Cordeiro Q, Michelon L, Sham P, Vallada H, Collier DA. Cho HJ, et al. Mol Psychiatry. 2005 Aug;10(8):771-81. doi: 10.1038/sj.mp.4001663. Mol Psychiatry. 2005. PMID: 15824745 Review. - A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders.
Anguelova M, Benkelfat C, Turecki G. Anguelova M, et al. Mol Psychiatry. 2003 Jun;8(6):574-91. doi: 10.1038/sj.mp.4001328. Mol Psychiatry. 2003. PMID: 12851635 Review.
Cited by
- Association of a functional polymorphism in the serotonin transporter gene with abnormal emotional processing in ecstasy users.
Roiser JP, Cook LJ, Cooper JD, Rubinsztein DC, Sahakian BJ. Roiser JP, et al. Am J Psychiatry. 2005 Mar;162(3):609-12. doi: 10.1176/appi.ajp.162.3.609. Am J Psychiatry. 2005. PMID: 15741482 Free PMC article. - The _5-HTTLPR_-rs25531 S-A-S-A Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda.
Kalungi A, Womersley JS, Kinyanda E, Joloba ML, Ssembajjwe W, Nsubuga RN, Seedat S, Hemmings SMJ. Kalungi A, et al. Front Genet. 2021 Apr 23;12:649055. doi: 10.3389/fgene.2021.649055. eCollection 2021. Front Genet. 2021. PMID: 33968131 Free PMC article. - Recent progress in the search for genes for bipolar disorder.
Kelsoe JR. Kelsoe JR. Curr Psychiatry Rep. 1999 Dec;1(2):135-40. doi: 10.1007/s11920-999-0022-0. Curr Psychiatry Rep. 1999. PMID: 11122915 Review. - Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study.
Zhao J, Goldberg J, Bremner JD, Vaccarino V. Zhao J, et al. Psychosom Med. 2013 Jul-Aug;75(6):523-9. doi: 10.1097/PSY.0b013e3182924cf4. Epub 2013 Jun 13. Psychosom Med. 2013. PMID: 23766378 Free PMC article. - Depression in people with coronary heart disease: prognostic significance and mechanisms.
Dickens C. Dickens C. Curr Cardiol Rep. 2015 Oct;17(10):83. doi: 10.1007/s11886-015-0640-6. Curr Cardiol Rep. 2015. PMID: 26277367 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical