Monoallelic expression of the interleukin-2 locus - PubMed (original) (raw)
Monoallelic expression of the interleukin-2 locus
G A Holländer et al. Science. 1998.
Abstract
The lymphokine interleukin-2 (IL-2) is responsible for autocrine cell cycle progression and regulation of immune responses. Uncontrolled secretion of IL-2 results in adverse reactions ranging from anergy, to aberrant T cell activation, to autoimmunity. With the use of fluorescent in situ hybridization and single-cell polymerase chain reaction in cells with different IL-2 alleles, IL-2 expression in mature thymocytes and T cells was found to be tightly controlled by monoallelic expression. Because IL-2 is encoded at a nonimprinted autosomal locus, this result represents an unusual regulatory mode for controlling the precise expression of a single gene.
Comment in
- Expansion of the allelic exclusion principle?
Chess A. Chess A. Science. 1998 Mar 27;279(5359):2067-8. doi: 10.1126/science.279.5359.2067. Science. 1998. PMID: 9537917 No abstract available.
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